Results 21 to 30 of about 4,652 (165)

Pharmacological analysis of the feeding response of codling moth (Cydia pomonella; Lepidoptera: Tortricidae) neonates to bitter compounds

European Journal of Entomology, 2017
Feeding in codling moth neonate caterpillars was inhibited by 0.67 mM and 2.24 mM concentrations of denatonium benzoate. This inhibitory effect was abolished by phospholipase C inhibitor, U-73122 and the phosphodiesterase inhibitor, Rolipram. Quinine and
Maciej A. PSZCZOLKOWSKI
doaj   +1 more source

Artesunate: The Best Drug in the Treatment of Severe and Complicated Malaria

Pharmaceuticals, 2010
This review summarizes progress in treating severe and complicated malaria, which are global problems, claiming at least one million lives annually, and have been accompanied by advances in our understanding of the pathogenesis of severe malaria ...
Qigui Li, Peter Weina
doaj   +1 more source

Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis. [PDF]

PLoS ONE, 2015
Intestinal circulatory disturbances, atony, edema and swelling are of great clinical relevance, but the related mechanisms and possible therapeutic options are poorly characterized, in part because of the difficulties to comprehensively analyze these ...
Ingmar Lautenschläger, Inéz Frerichs, Heike Dombrowsky, Jürgen Sarau, Torsten Goldmann, Karina Zitta, Martin Albrecht, Norbert Weiler, Stefan Uhlig   +8 more
doaj   +1 more source

Quinidine: an “Endangered Species” Drug Appropriate for Management of Electrical Storm in Brugada Syndrome

Indian Pacing and Electrophysiology Journal, 2013
Brugada syndrome is an inherited channelopathy associated with an increased risk of syncope and sudden cardiac death. In rare cases it can be manifested with electrical storm.
Stelios Paraskevaidis, MD, PhD, Efstratios K. Theofilogiannakos, MD, PhD, Vasileios Kamperidis, MD, Yiannis S. Chatzizisis, MD, PhD, Konstantinos Tsilonis, MD, Vassilios P. Vassilikos, MD, PhD, George Dakos, MD, PhD, George Stavropoulos, MD, Antonios Ziakas, MD, PhD, Stavros Hadjimiltiades, MD, PhD, Ioannis H. Styliadis, MD, PhD   +10 more
doaj   +1 more source

Exploring the Role of the KCNK1 Potassium Channel and Its Inhibition Using Quinidine in Treating Head and Neck Squamous Cell Carcinoma [PDF]

Clinical and Experimental Otorhinolaryngology
Objectives. Our study aimed to explore the role of the potassium channel KCNK1 in head and neck squamous cell carcinoma, focusing on its impact on tumor growth, invasion, and metastasis.
Hyun Woo Baek, Eunjung Han, Kyoung Ho Oh
doaj   +1 more source

Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4, P‐gp, and CYP2D6 drug–drug–gene interaction network

CPT: Pharmacometrics & Systems Pharmacology, 2023
The antiarrhythmic agent quinidine is a potent inhibitor of cytochrome P450 (CYP) 2D6 and P‐glycoprotein (P‐gp) and is therefore recommended for use in clinical drug–drug interaction (DDI) studies.
Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, Sebastian Frechen, Maaike van derLee, Dirk Jan A. R. Moes, Jesse J. Swen, Matthias Schwab, Thorsten Lehr   +11 more
doaj   +1 more source

A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. [PDF]

PLoS Genetics, 2014
The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium ...
Cecilia P Sanchez, Chia-Hao Liu, Sybille Mayer, Astutiati Nurhasanah, Marek Cyrklaff, Jianbing Mu, Michael T Ferdig, Wilfred D Stein, Michael Lanzer   +8 more
doaj   +1 more source

Incidence, recurrence and management of electrical storm in Brugada syndrome

Frontiers in Cardiovascular Medicine, 2022
BackgroundBrugada syndrome (BrS) is associated with ventricular tachyarrhythmias. However, the presence of electrical strom (ES) and its management still debated.ObjectivesWe present the outcome and management of 44 BrS patients suffering from ES ...
Ibrahim El-Battrawy, Ibrahim El-Battrawy, Ibrahim El-Battrawy, Gretje Roterberg, Jacqueline Kowitz, Assem Aweimer, Siegfried Lang, Siegfried Lang, Andreas Mügge, Xiaobo Zhou, Xiaobo Zhou, Ibrahim Akin, Ibrahim Akin   +12 more
doaj   +1 more source

Fluoxetine Treatment in Epilepsy of Infancy with Migrating Focal Seizures Due to KCNT1 Variants: An Open Label Study

Annals of Neurology, EarlyView.
Objective Gain‐of‐function (GoF) variants in KCNT1 encoding for potassium channels are associated with different epilepsy phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), other early infantile developmental and epileptic encephalopathies, and focal epilepsy.
Marina Trivisano, Ilaria Mosca, Licia Salimbene, Angela De Dominicis, Paolo Ambrosino, Deborah Puzo, Ilenio Servettini, Cinzia Correale, Chiara Falamesca, Cristina Filosomi, Bianca Goffredo, Maria Virginia Soldovieri, Maurizio Taglialatela, Nicola Specchio   +13 more
wiley   +1 more source

In silico identification of clinically approved medicines against the main protease of SARS-CoV-2, causative agent of covid-19 [PDF]

arXiv, 2020
The COVID-19 pandemic triggered by SARS-CoV-2 is a worldwide health disaster. Main protease is an attractive drug target among coronaviruses, due to its vital role in processing the polyproteins that are translated from the viral RNA. There is presently no exact drug or treatment for this diseases caused by SARS-CoV-2.
arxiv