Results 21 to 30 of about 31,179 (232)

Therapeutic Drug Monitoring of Quinidine in Pediatric Patients with KCNT1 Genetic Variants

open access: yesPharmaceutics, 2022
Quinidine (QND) is an old antimalarial drug that was used in the early 20th century as an antiarrhythmic agent. Currently, QND is receiving attention for its use in epilepsy of infancy with migrating focal seizures (EIMFS) due to potassium sodium ...
Alessandro Ferretti   +7 more
doaj   +1 more source

Electrical storm in an acquired short QT syndrome successfully treated with quinidine

open access: yesClinical Case Reports, 2019
Short QT syndrome (SQTS) is a malignant heart disorder defined by the presence of ventricular arrhythmias causing syncope and sudden cardiac arrest. The prevalence in the pediatric population is 0.05%.
Michael Spartalis   +3 more
doaj   +1 more source

Involvement of Multidrug Resistance Modulators in the Regulation of the Mitochondrial Permeability Transition Pore

open access: yesMembranes, 2022
The permeability transition pore in mitochondria (MPTP) and the ATP-binding cassette transporters (АВС transporters) in cell membranes provide the efflux of low-molecular compounds across mitochondrial and cell membranes, respectively.
Tatiana Fedotcheva   +2 more
doaj   +1 more source

Organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium or azolium enolates [PDF]

open access: yes, 2014
This tutorial review highlights the organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium/azolium enolates.
Morrill, Louis C., Smith, Andrew D.
core   +1 more source

Botulinum toxin for the treatment of lower limb cramp pain in patients with Amyotrophic Lateral Sclerosis [PDF]

open access: yes, 2020
Background: Muscle cramps and pain associated with them can be seen in patients with amyotrophic lateral sclerosis (ALS) and are known to reduce the quality of life. Pharmacological treatment may not benefit all patients in treating these cramps.
Govindarajan, Raghav   +2 more
core   +2 more sources

Pharmacological analysis of the feeding response of codling moth (Cydia pomonella; Lepidoptera: Tortricidae) neonates to bitter compounds

open access: yesEuropean Journal of Entomology, 2017
Feeding in codling moth neonate caterpillars was inhibited by 0.67 mM and 2.24 mM concentrations of denatonium benzoate. This inhibitory effect was abolished by phospholipase C inhibitor, U-73122 and the phosphodiesterase inhibitor, Rolipram. Quinine and
Maciej A. PSZCZOLKOWSKI
doaj   +1 more source

Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine [PDF]

open access: yes, 2010
pH-regulated Slo3 channels, perhaps exclusively expressed in mammalian sperm, may play a role in alkalization-mediated K(+) fluxes associated with sperm capacitation.
Lingle, Christopher J   +3 more
core   +2 more sources

Artesunate: The Best Drug in the Treatment of Severe and Complicated Malaria

open access: yesPharmaceuticals, 2010
This review summarizes progress in treating severe and complicated malaria, which are global problems, claiming at least one million lives annually, and have been accompanied by advances in our understanding of the pathogenesis of severe malaria ...
Qigui Li, Peter Weina
doaj   +1 more source

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