Results 41 to 50 of about 31,612 (240)

In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.

PLoS ONE, 2017
AimsShort QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr)
Cunjin Luo, Kuanquan Wang, Henggui Zhang
doaj   +1 more source

Incidence, recurrence and management of electrical storm in Brugada syndrome

Frontiers in Cardiovascular Medicine, 2022
BackgroundBrugada syndrome (BrS) is associated with ventricular tachyarrhythmias. However, the presence of electrical strom (ES) and its management still debated.ObjectivesWe present the outcome and management of 44 BrS patients suffering from ES ...
Ibrahim El-Battrawy, Ibrahim El-Battrawy, Ibrahim El-Battrawy, Gretje Roterberg, Jacqueline Kowitz, Assem Aweimer, Siegfried Lang, Siegfried Lang, Andreas Mügge, Xiaobo Zhou, Xiaobo Zhou, Ibrahim Akin, Ibrahim Akin   +12 more
doaj   +1 more source

Ventricular fibrillation in experimental hypothermic cardiac surgery, the evaluation of antifibrillary agents [PDF]

, 1959
Thesis (M.A.)--Boston ...
Anlyan, Frederick H.
core   +2 more sources

Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

eLife
Quinidine has been used as an anticonvulsant to treat patients with KCNT1-related epilepsy by targeting gain-of-function KCNT1 pathogenic mutant variants.
Tian Yuan, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang   +17 more
doaj   +1 more source

Organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium or azolium enolates [PDF]

, 2014
This tutorial review highlights the organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium/azolium enolates.
Morrill, Louis C., Smith, Andrew D.
core   +1 more source

Halide Bond Assisted Double Desymmetrization of Meso‐Dicarboxylic Acids with Symmetrical Olefins via Asymmetric Halogenation

Angewandte Chemie International Edition, EarlyView.
This work demonstrates a double desymmetrization of meso‐dicarboxylic acids with symmetrical olefins, constructing complex chiral lactones with six stereocenters in one step. Unexpectedly, the halide bond was found to be crucial in achieving high stereoselectivity.
Qingyu Zhang, Haihui Wang, Ying‐Lung Steve Tse, Ying‐Yeung Yeung   +3 more
wiley   +1 more source

The Fever Tree: from Malaria to Neurological Diseases

Toxins, 2018
This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine.
Sara Eyal
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

Frontiers in Physiology, 2017
The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, IKr, underlie SQTS variant 1 (SQT1), in which treatment ...
Dominic G. Whittaker, Haibo Ni, Alan P. Benson, Alan P. Benson, Jules C. Hancox, Jules C. Hancox, Henggui Zhang, Henggui Zhang, Henggui Zhang   +8 more
doaj   +1 more source

Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine [PDF]

, 2010
pH-regulated Slo3 channels, perhaps exclusively expressed in mammalian sperm, may play a role in alkalization-mediated K(+) fluxes associated with sperm capacitation.
Lingle, Christopher J, Tang, Qiong-Yao, Xia, Xiao-Ming, Zhang, Zhe   +3 more
core   +2 more sources