Results 41 to 50 of about 4,652 (165)

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability

Frontiers in Physiology, 2017
Background:In silico modeling could soon become a mainstream method of pro-arrhythmic risk assessment in drug development. However, a lack of human-specific data and appropriate modeling techniques has previously prevented quantitative comparison of drug
Oliver J. Britton, Najah Abi-Gerges, Guy Page, Andre Ghetti, Paul E. Miller, Blanca Rodriguez   +5 more
doaj   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, EarlyView.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source

Enhanced Proliferation and Potassium Conductance of Schwann Cells Isolated from NF2 Schwannomas Can Be Reduced by Quinidine

Neurobiology of Disease, 2000
Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that is characterized mainly by schwannomas, as well as menigiomas and gliomas. The NF2 gene product merlin/schwannomin acts as a tumor suppressor. Schwann cells derived from NF2 schwannomas
C. Rosenbaum, M. Kamleiter, P. Grafe, L. Kluwe, V.-F. Mautner, H.W. Müller, C.O. Hanemann   +6 more
doaj  

Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection. [PDF]

PLoS Neglected Tropical Diseases, 2018
Heme crystallization as hemozoin represents the dominant mechanism of heme disposal in blood feeding triatomine insect vectors of the Chagas disease. The absence of drugs or vaccine for the Chagas disease causative agent, the parasite Trypanosoma cruzi ...
Caroline M Ferreira, Renata Stiebler, Francis M Saraiva, Guilherme C Lechuga, Ana Beatriz Walter-Nuno, Saulo C Bourguignon, Marcelo S Gonzalez, Patrícia Azambuja, Ana Caroline P Gandara, Rubem F S Menna-Barreto, Gabriela O Paiva-Silva, Marcia C Paes, Marcus F Oliveira   +12 more
doaj   +1 more source

Evaluation of propranolol and quinidine in the treatment of quinidine-resistant arrhythmias [PDF]

The American Journal of Cardiology, 1971
Abstract Combining propranolol and quinidine should improve the antiarrhythmic action of quinidine by blocking beta adrenergic receptors, an action helpful in cases of arrhythmias associated with anesthetic agents, digitalis and stress. To test this hypothesis, 60 patients with paroxysmal arrhythmias resistant to quinidine and 17 with chronic atrial ...
Fors, Jr. , William J., Vander Ark, Condon R., Reynolds, Jr. , Ernest W.   +2 more
openaire   +4 more sources

Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes.

PLoS Computational Biology, 2021
Short QT (SQT) syndrome is a genetic cardiac disorder characterized by an abbreviated QT interval of the patient's electrocardiogram. The syndrome is associated with increased risk of arrhythmia and sudden cardiac death and can arise from a number of ion
Karoline Horgmo Jæger, Samuel Wall, Aslak Tveito   +2 more
doaj   +1 more source

Comparison between Inhibition of CatSper and KSper Channels with NNC 55-0396 and Quinidine on Human Sperm Function [PDF]

Iranian Journal of Medical Sciences
Background: Calcium enters human sperm through the “Cation Channel of Sperm” (CatSper), while potassium ions exit via the sperm potassium channel (KSper).
Ali Asghar Zarei, Sara Keshtgar, Masoud Haghani, Negar Firouzabadi, Mohammad Hossein Nasr-Esfahani   +4 more
doaj   +1 more source

Rilzabrutinib for the Treatment of Immune Thrombocytopenia

European Journal of Haematology, EarlyView.
ABSTRACT Advancements in the understanding of ITP pathogenesis have led to significant improvements in disease management through the use of both traditional immunosuppressive strategies and novel targeted therapies. However, a subset of patients remains refractory to treatment or achieves only transient benefits, underscoring the need for alternative ...
Caterina Labanca, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Francesco Mendicino, Giulio Caridà, Eugenio Lucia, Virginia Olivito, Veronica Manicardi, Nicola Amodio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Quinoline Alkaloids in Suspension Cultures of Cinchona ledgeriana Treated with Various Substances

Hayati Journal of Biosciences, 2010
Cinchona alkaloids are in extensive uses, not only for drugs but also for soft drink industries. They are harvested from the bark of trees Cinchona spp. after certain ages and therefore are available over a limited time.
DIAH RATNADEWI, SUMARYONO
doaj   +3 more sources

In vitro evaluation of quinidine sensitivity in brazilian Plasmodium falciparum isolates: comparative analysis to quinine and chloroquine Avaliação da sensibilidade in vitro à quinidina em isolados brasileiros de Plasmodium falciparum: análise comparativa à quinina e à cloroquina

Revista do Instituto de Medicina Tropical de São Paulo, 2001
Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite's resistance to the most available drugs.
Carla M. S. MENEZES, Karin KIRCHGATTER, Sílvia Maria DI SANTI, Gilberto A. PAULA, Elizabeth I. FERREIRA   +4 more
doaj   +1 more source