Results 51 to 60 of about 4,652 (165)
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Introduction Right bundle branch block (RBBB) following cardiac device extraction has not been previously reported but may have catastrophic consequences. Methods and Results We present two cases of young male patients who developed RBBB following the extraction of single chamber TV ICD systems where the coil was adherent close to the superior
Karanjeet Chauhan +4 more
wiley +1 more source
Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats
Drug Design, Development and Therapy, 2019 Qiong Wang,1 Haiyun Wang,1 Youyan Zhong,1 Qiang Zhang2 1Department of Pharmacy, Wenzhou People’s Hospital, Wenzhou, Zhejiang 325000, People’s Republic of China; 2Department of Clinical Laboratory, The People’s Hospital of Lishui, Lishui,
Wang Q, Wang H, Zhong Y, Zhang Q
doaj
The Journal of Physiology, EarlyView.Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger +4 more
wiley +1 more source
Electrical Storms in Brugada Syndrome: Review of Pharmacologic and Ablative Therapeutic Options
Indian Pacing and Electrophysiology Journal, 2005 Electrical storm occurring in a patient with the Brugada syndrome is an exceptional but malignant and potentially lethal event. Efficient therapeutic solutions should be known and urgently applied because of the inability of usual antiarrhythmic means in
Maury P, Hocini M, Haïssaguerre M
doaj
Persistence of EEG abnormalities in KCNT1‐related DEE in an adult patient
Epileptic Disorders, EarlyView.
Haania Kakwan +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 9, Page 1879-1896, May 2025.Abstract Background and Purpose Phentolamine is a non‐selective α‐adrenoreceptor antagonist used to reverse local anaesthesia, for example, during dental procedures when a vasoconstrictor is co‐applied. Phentolamine‐mediated vasodilation leads to faster clearance of injected drugs.
Idil Toklucu +8 more
wiley +1 more source
Mechanistic Investigation of an Organocatalytic Bromocyclization of O‐Allyl Carbamates
ChemCatChem, Volume 17, Issue 8, April 15, 2025.The enantioselective bromoaminocyclization of O‐cinnamyl tosylcarbamates catalyzed by thiourea‐functionalized Cinchona alkaloids achieved 80:20 er and 69% isolated yield. Experimental and theoretical studies reveal key bromonium intermediates and non‐covalent interactions stabilizing the catalytic structure. This model reaction elucidates the mechanism
Francisco Wanderson Moreira Ribeiro +5 more
wiley +1 more source
Determination of the pKaH of Established Isothiourea Catalysts
European Journal of Organic Chemistry, Volume 28, Issue 13, April 1, 2025.The pKaH of a series of privileged (chiral) isothiourea organocatalysts in acetonitrile and DMSO was determined by using a chemical shift imaging NMR methodology. Abstract Isothioureas (ITUs) represent a powerful family of (chiral) Lewis base organocatalysts.
Lukas S. Vogl +2 more
wiley +1 more source
QUINIDINE IN FALCIPARUM MALARIA
The Lancet, 1981 Fourteen patients with falciparum malaria were successfully treated with oral quinidine. Twelve of these patients were followed for 35 days without recrudescence. In six patients the infection had already recrudesced after antimalarial treatment, which in two cases had included a full course of quinine.
Nicholas J. White +11 more
openaire +3 more sources
The Journal of Clinical Pharmacology, Volume 65, Issue 4, Page 508-519, April 2025.Abstract Fezolinetant is an oral, nonhormonal, neurokinin 3 receptor antagonist treatment option for moderate to severe vasomotor symptoms associated with menopause. An in vitro study using human recombinant cytochrome P450 (CYP) enzymes and human liver microsomes showed that fezolinetant is metabolized to its major but inactive metabolite, ES259564 ...
Megumi Iwai +8 more
wiley +1 more source