Results 71 to 80 of about 16,625 (226)
The Journal of Physiology, EarlyView.Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato +3 more
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Efficacy and Limitations of Quinidine in Patients with Brugada Syndrome
, 2019 Background Quinidine at high dose is suggested as antiarrhythmic treatment in patients with Brugada Syndrome (BrS), but its efficacy to prevent life-threatening arrhythmic events (LAE) in this population is unproven and its use limited by frequent side ...
Pagan E. +17 more
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Quinoline Alkaloids in Suspension Cultures of Cinchona ledgeriana Treated with Various Substances
Hayati Journal of Biosciences, 2010 Cinchona alkaloids are in extensive uses, not only for drugs but also for soft drink industries. They are harvested from the bark of trees Cinchona spp. after certain ages and therefore are available over a limited time.
DIAH RATNADEWI, SUMARYONO
doaj +3 more sources
Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats
Drug Design, Development and Therapy, 2019 Qiong Wang,1 Haiyun Wang,1 Youyan Zhong,1 Qiang Zhang2 1Department of Pharmacy, Wenzhou People’s Hospital, Wenzhou, Zhejiang 325000, People’s Republic of China; 2Department of Clinical Laboratory, The People’s Hospital of Lishui, Lishui,
Wang Q, Wang H, Zhong Y, Zhang Q
doaj
Frontiers in Physiology, 2019 Short QT syndrome variant 1 (SQT1) arises due to gain-of-function mutations to the human Ether-à-go-go-Related Gene (hERG), which encodes the α subunit of channels carrying rapid delayed rectifier potassium current, IKr.
Dominic G. Whittaker +7 more
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PLoS Computational Biology, 2021 Short QT (SQT) syndrome is a genetic cardiac disorder characterized by an abbreviated QT interval of the patient's electrocardiogram. The syndrome is associated with increased risk of arrhythmia and sudden cardiac death and can arise from a number of ion
Karoline Horgmo Jæger +2 more
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Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source
Subunit-specific inhibition of inward-rectifier K+ channels by quinidine
, 1995 Distinct inward-rectifier K+ channel subunits were expressed in Xenopus oocytes and tested for their sensitivity to the channel blocker quinidine. The ‘strong’ inward-rectifier K+ channel IRK1 was inhibited by quinidine with an EC50 of 0.7 mM, while the ‘
Zenner, H.-P. +19 more
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A review Commentary on Quinidine kinetics (PK modelling)
, 2020 This article takes you through the possible pharmacokinetic models and parameters for the antiarrhythmic drug Quinidine. The shuffle between the linear and non-linear pharmacokinetics of quinidine make it a candidate for therapeutic drug monitoring.
Beg, Mohd Riyaz, Mohd Riyaz Beg
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Drug Critical Limits for Urgent Physician Notification
Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 178-192, July 2026.Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang +3 more
wiley +1 more source