Results 91 to 100 of about 16,625 (226)

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding

, 2005
We have previously shown that Phe120, Glu216, and Asp301 in the active site of cytochrome P450 2D6 (CYP2D6) play a key role in substrate recognition by this important drug-metabolizing enzyme (Paine, M. J., McLaughlin, L. A., Flanagan, J. U., Kemp, C. A.,
Paine, Mark J.I., Kemp, Carol A., Flanagan, Jack U., McLaughlin, Lesley, A., Roberts, Gordon, C.K., Maréchal, Jean Didier, Gordon C.K. Roberts (7582808), Ward, Clive J., Mark J.L. Paine (7582799), Michael J. Sutcliffe (2074798), J.U. Flanagan (7582802), Kemp, Carol, A., Sutcliffe, Michael J., Paine, Mark, J.I., Ward, Clive, J., Lesley A. McLaughlin (7582796), Flanagan, Jack, U., Paine, Mark J I, Clive J. Ward (7582805), C. Roland Wolf (293805), Roberts, Gordon C K, Carol A. Kemp (2704681), Maréchal, Jean-Didier, Sutcliffe, Michael, J., McLaughlin, Lesley A., Jean-Didier Maréchal (112016), Wolf, C. Roland, Roberts, Gordon C.K.   +27 more
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Left Ventricular Global Longitudinal Strain Is Associated With Appropriate Therapies for Ventricular Arrhythmias Independent of Left Ventricular Ejection Fraction in Patients With Primary Prevention Defibrillators

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Reduced (absolute value) left ventricular global longitudinal strain is independently associated with an increased risk of appropriate therapies from primary prevention implantable cardioverter defibrillators. ABSTRACT Background Left ventricular ejection fraction (LVEF) has not demonstrated reliability in predicting ventricular arrhythmias or ...
Justin Rackley, Muhammad Soofi, Gregory M. Burkman, Carlos Contreras, Habib Yazgi, Mario D. Gonzalez, Gerald V. Naccarelli, Ankit Maheshwari   +7 more
wiley   +1 more source

Digoxin-quinidine interaction in the neonatal dog

, 1986
The effects of quinidine on steady state serum and tissue digoxin concentrations in the neonatal dog were studied. To determine the effects of quinidine on serum digoxin concentrations, two groups of neonates were evaluated: Group I (n = 11) was ...
Gelband, Henry, Stolfi, Adrienne, Pickoff, Arthur S.   +2 more
core   +1 more source

Quinidine hypersensitivity: a side effect of a forgotten antiarrhythmic

, 2020
Quinidine is one of the oldest antiarrhythmics known. Over the years, its use has decreased along with its side effects. Our case describes a 69-year-old woman with recurrent resistant ventricular tachycardia on Quinidine and Amiodarone who presented ...
El-khatib, Layan, Alrayes, Hussayn, Elbanna, Ahmed, Elkhatib, Layan, Sallam, Omar   +4 more
core   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

A Possible Mechanism of Action of Quinidine

, 1957
Quinidine increases the refractory period and depresses both the rate and amplitude of beat of isolated rabbit atria. These effects can be enhanced by elevating the K content of the medium twofold and completely blocked by lowering the K to one ...
W. C. Holland
core   +1 more source

Treatment of pseudobulbar affect in a mixed neurodegenerative disorder with compounded quinidine capsules and dextromethorphan cough syrup

SAGE Open Medical Case Reports, 2020
An elderly woman admitted in our geriatric inpatient unit suffered from disturbing outbursts of crying and, less frequently, episodes of laughing. The patient was diagnosed with pseudobulbar affect related to a mixed neurodegenerative disorder.
Yannick Villeneuve, Diana Cruz-Santiago, Helene Masson, Doris Clerc   +3 more
doaj   +1 more source

Metal Nanoparticles on Halloysite Applied in Stereoselective Hydrogenation of Tetrasubstituted Alkenes

Chemistry – A European Journal, Volume 32, Issue 20, 27 May 2026.
Composite materials based on metal nanoparticles supported on a naturally occurring nanotubular clay, halloysite (HAL), led to the diastereoselective hydrogenation of tetra‐substituted alkenes under relatively smooth conditions, mainly oxazolidinone‐based heterocycles.
Rosa Pich, Gabriel Domínguez, Leo Westrey, Pierre Lavedan, Sonia Mallet‐Ladeira, Jérôme Esvan, Jean‐François Lahitte, Jean‐Christophe Remigy, Daniel Pla, Montserrat Gómez   +9 more
wiley   +1 more source

Quinidine-induced hepatitis and thrombocytopenia

, 1977
Quindlne-induced hepatitis has received more attention only recently whereas quinidine-induced thrombocytopenia is well recognized. Over the past two years the authors saw four patients with quinidine-hepatitis accompanied by malaise, anorexia, fever in ...
Alam, Mohsin, Duvernoy, Wolf F. C., Pickard, Sol D., Aronsohn, Paul L.   +3 more
core  

Abnormal quinidine binding in survivors of prehospital cardiac arrest

, 1984
Quinidine binding was studied in 15 survivors of prehospital cardiac arrest and was compared to 18 normal individuals and 20 patients with coronary artery disease.
Kessler, Kenneth M, Silver, June, Lisker, Bernhard, Conde, Caesar, Hamburg, Curtis, Ho-Tung, Peter, Myerburg, Robert J   +6 more
core   +1 more source