Results 111 to 120 of about 16,625 (226)
Extensive Metabolizers of Debrisoquine Become Poor Metabolizers during Quinidine Treatment
, 1987 Seven male patients (age 55–75 years) were debrisoquine‐tested immediately before and after one week of treatment with quinidine sulphate (200 mg x 3‐4 day‐1). Before quinidine all patients were classified as extensive metabolizers (metabolic ratio 0.1‐3.
Bertilsson, L. +3 more
core +1 more source
One of the earliest antiarrhythmic drugs developed, quinidine had a significant role in the treatment of many arrhythmias. After concerns for increased risk of ventricular arrhythmia and death with quinidine emerged, the use of quinidine fell ...
Yang, Felix
core
Structures of the epimers quinine and quinidine.
, 2013 Structures of the epimers quinine and quinidine.
Brendan J. Howlin (104145) +2 more
core +1 more source
Inhibitory effects of quinidine on rat heart muscarinic receptors
, 1984 Quinidine inhibited binding of the labelled agonist [3H]oxotremorine M ([3HOxo-M) and the labelled antagonist [3H]N-methylscopolamine ([3H]NMS) to rat heart muscarinic receptors. Kinetic studies demonstrated that quinidine decreased the association rates
De Neef, Philippe +3 more
core +1 more source
Digoxin-quinidine interaction in patients with chronic renal failure.
, 1982 We evaluated the effect of quinidine on digoxin pharmacokinetic in six patients with severe renal failure. Quinidine reduced the total body clearance of digoxin from 1.87 to 1.06 l/hour (p less than 0.001), and prolonged the digoxin half-life of ...
J R Powell +5 more
core +1 more source
Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart
, 1990 The ATP-sensitive potassium channel current (IK-ATP) was studied in excised inside-out patches from rat ventricular cells at 20-23 degrees C. The bath solution contained 140 mM KF, and the pipette solution contained 140 mM KCl and 1.2 mM MgCl2. ATP (0.5
I. Fleidervish +6 more
core +1 more source
Potentiation of the antidepressant-like effects of dextromethorphan by quinidine.
, 2014 A single dose of the CYP2D6 inhibitor quinidine (30 mg/kg, i.p.) administered concomitantly with dextromethorphan (0–30 mg/kg, i.p.) significantly potentiated the decrease in immobility time for dextromethorphan at 10 mg/kg (A).
Anna L. Scandinaro (529242) +4 more
core +1 more source
Sparteine oxidation is practically abolished in quinidine‐treated patients
, 1986 In eight patients a sparteine‐test was carried out immediately before and after 1 week of treatment with quinidine 600‐800 mg day‐1. Before treatment one patient was classified as a poor metaboliser (metabolic ratio: greater than or equal to 20), and ...
Otton, SV +4 more
core +1 more source
8-Br-cGMP activates HSPB6 and increases the antineoplastic activity of quinidine in prostate cancer
Cell Death DiscoveryHeat shock protein family B [small] member 6 (HSPB6), widely found in various muscles, has been recently identified as a tumor suppressor gene. However, its role in prostate cancer remains unexplored.
Yuankang Feng +14 more
doaj +1 more source
Inhibition of ATP levels by quinidine in a human colonic epithelial cell line
, 1986 The influence of quinidine, a putative K+ channel blocker, on Cl- secretion induced by vasoactive intestinal polypeptide (VIP) was investigated. Quinidine inhibited Cl- secretion induced by VIP in T84 cell monolayers.
K. Dharmsathaphorn +5 more
core +1 more source