Results 81 to 90 of about 31,612 (240)
Electrical Synapses Contribute to Sleep‐Dependent Declarative Memory Retention
Blocking electrical synapses (gap junctions) in healthy humans by mefloquine impaired the sleep‐dependent retention of verbal declarative memory and improved sensorimotor memory consolidation irrespective of sleep. Mefloquine also disrupted the coupling of sleep spindles to EEG slow oscillations in humans but did not affect hippocampal sharp‐wave ...
Gordon B. Feld +9 more
wiley +1 more source
In Silico Screening and Designing Synthesis of Cinchona Alkaloids Derivatives as Potential Anticancer [PDF]
P-glycoprotein (P-gp) resistance in cancer cells decreases intracellular accumulation of various anticancer drugs. This multidrug resistance (MDR) protein can be modulated by a number of non-cytotoxic drugs.
Hanafi, M. (Muhammad) +4 more
core +2 more sources
In this real‐world study among 14,459 adults with MG, exposure to any contraindicated treatment was not significantly associated with risk of ICU admission for MG but was associated with significantly higher risk of death. In contrast, statins were associated with a greater risk of ICU admission but a lower risk of death.
Guilhem Solé +7 more
wiley +1 more source
Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite's resistance to the most available drugs.
Carla M. S. MENEZES +4 more
doaj +1 more source
Pharmacology of Antiarrhythmics: Quinidine, Beta-Blockers, Diphenylhydantoin, Bretylium [PDF]
The electrophysiologic effects of the antiarrhythmic drugs, presented elsewhere in this symposium, form only one of the bases for the selection of a therapeutic agent in any given clinical situation.
Proctor, Jack D., Wasserman, Albert J.
core +1 more source
Reducing the oral quinine-quinidine-cinchonin (Quinimax) treatment of uncomplicated malaria to three days does not increase the recurrence of attacks among children living in a highly endemic area of Senegal [PDF]
A 3 d shortened course of the quinine-quinidine-cinchonin association Quinimax (trademark) was compared to the usual 7 d regimen for routinely treating 462 acute uncomplicated #Plasmodium falciparum$ malaria attacks in 72 children under the age of 10 ...
Brau, R. +4 more
core +1 more source
ABSTRACT Introduction Obstructive sleep apnea (OSA) is a common risk factor for the development and progression of atrial fibrillation (AF). Whether catheter ablation for AF management in patients with coexisting OSA yields survival benefit remains unclear.
Ghassan Bidaoui +16 more
wiley +1 more source
PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury [PDF]
BACKGROUND: Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS).
Alexander, David N. +12 more
core +4 more sources
Isophorone is an important motif in synthetic organic chemistry, as it is highly reactive and can get involved in a diverse array of functional group transformations to access various synthetic intermediates and molecular targets. In this context, an important group of compounds is the conjugated or nonconjugated isophorone‐cored dienones, which are ...
M. Saeed Abaee +2 more
wiley +1 more source
The catalytic enantioselective epoxidation of acyclic tetrasubstituted alkenes, bearing a trifluoromethyl group, is reported. In the presence of Takemoto's thiourea organocatalyst and tert‐butyl hydroperoxide, epoxides are obtained with excellent yield and good to high enantioselectivity.
Vincenzo Battaglia +4 more
wiley +1 more source

