Results 81 to 90 of about 31,065 (253)

Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes.

PLoS Computational Biology, 2021
Short QT (SQT) syndrome is a genetic cardiac disorder characterized by an abbreviated QT interval of the patient's electrocardiogram. The syndrome is associated with increased risk of arrhythmia and sudden cardiac death and can arise from a number of ion
Karoline Horgmo Jæger, Samuel Wall, Aslak Tveito   +2 more
doaj   +1 more source

Glycine Betaine Fluxes in Lactobacillus plantarum during Osmostasis and Hyper- and Hypo-osmotic Shock [PDF]

, 1996
Bacteria respond to changes in medium osmolarity by varying the concentrations of specific solutes in order to maintain constant turgor. The primary response of Lactobacillus plantarum to an osmotic upshock involves the accumulation of compatible solutes
Glaasker, Erwin,, Konings, Wil N.,, Poolman, Bert,   +2 more
core   +2 more sources

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

The Journal of Clinical Pharmacology, EarlyView.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Nancy Agrawal, Janet Hammond   +9 more
wiley   +1 more source

Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats

Drug Design, Development and Therapy, 2019
Qiong Wang,1 Haiyun Wang,1 Youyan Zhong,1 Qiang Zhang2 1Department of Pharmacy, Wenzhou People’s Hospital, Wenzhou, Zhejiang 325000, People’s Republic of China; 2Department of Clinical Laboratory, The People’s Hospital of Lishui, Lishui,
Wang Q, Wang H, Zhong Y, Zhang Q
doaj  

PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury [PDF]

, 2016
BACKGROUND: Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS).
Alexander, David N., Cutler, Andrew J., Davis, Charles S., Doody, Rachelle S., D’Amico, Stephen, Formella, Andrea E., Hammond, Flora M., Ledon, Fred, Sauve, William, Shin, Paul, Siffert, Joao, Yonan, Charles, Zorowitz, Richard D.   +12 more
core   +4 more sources

Buffer‐Mediated Catalyst‐Free Strecker Reaction Toward Enzymatic Implementation

ChemistryOpen, EarlyView.
Hydroxynitrile lyases (HNLs) are proven to accept imines as substrates and to catalyze the formation of α‐aminonitriles. The process results in the precursors of natural and unnatural α‐amino acids after extraction, without chromatography. This new application of HNL enzymes in Strecker reaction is an example for biocatalysis in multicomponent ...
Péter Magyar, Szilárd Újvári, Zsófia Molnár, Zoltán Orgován, Diána Balogh‐Weiser, Blanka Eszter Nagy, Diana Maria Scrob, László Poppe, Péter Ábrányi‐Balogh   +8 more
wiley   +1 more source

QUINIDINE IN FALCIPARUM MALARIA

The Lancet, 1981
Fourteen patients with falciparum malaria were successfully treated with oral quinidine. Twelve of these patients were followed for 35 days without recrudescence. In six patients the infection had already recrudesced after antimalarial treatment, which in two cases had included a full course of quinine.
Nicholas J. White, Nicholas J. White, Tan Chongsuphajaisiddhi, Tan Chongsuphajaisiddhi, David A. Warrell, David A. Warrell, Danai Bunnag, Danai Bunnag, Sornchai Looareesuwan, Sornchai Looareesuwan, Harinasuta T, Harinasuta T   +11 more
openaire   +3 more sources

Semiochemical applications for managing the grey field slug (Deroceras reticulatum Müller), a major pest of arable crops

Pest Management Science, EarlyView.
Trends in semiochemical research highlight promising attractants and repellents for ‘push–pull’ pest control strategies of the grey field slug. Extracts from plants, predators, entomopathogenic fungi, and essential oils demonstrate potential in modifying grey field slug behaviour, inducing avoidance, antifeeding responses, or mortality, offering ...
Suleiman Mustapha, E Joel Loveridge, Tariq M Butt, Jozsef Vuts, Patricia A Ortega‐Ramos, Samantha M Cook   +5 more
wiley   +1 more source

Classification of Platelet‐Activating Anti‐Platelet Factor 4 Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Theodore E. Warkentin
wiley   +1 more source

In vitro evaluation of quinidine sensitivity in brazilian Plasmodium falciparum isolates: comparative analysis to quinine and chloroquine Avaliação da sensibilidade in vitro à quinidina em isolados brasileiros de Plasmodium falciparum: análise comparativa à quinina e à cloroquina

Revista do Instituto de Medicina Tropical de São Paulo, 2001
Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite's resistance to the most available drugs.
Carla M. S. MENEZES, Karin KIRCHGATTER, Sílvia Maria DI SANTI, Gilberto A. PAULA, Elizabeth I. FERREIRA   +4 more
doaj   +1 more source