Results 121 to 130 of about 60,018 (242)
Archiv der Pharmazie, Volume 359, Issue 10, October 2026.Of 22 chloroquine (CQ) analogs, 16 showed IC503D7 values of 27–555 nM; their activity against the CQ‐resistant K1 strain and in silico/vitro hepatotoxicity were evaluated. Benzamides with chlorine and nitro groups were most active, showing IC50K1 and RI values lower than CQ and cytotoxic concentrations well above inhibitory concentrations.
Everton P. Silva +8 more
wiley +1 more source
Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients
British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3375-3386, October 2026.Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen +14 more
wiley +1 more source
Quinine-induced severe thrombocytopenia: the importance of taking a detailed drug history
, 2013 Drugs can lead to severe life-threatening thrombocytopenia. The mechanisms of drug-induced thrombocytopenia are increased destruction by immunemediated platelet destruction or decreased platelet production by bone marrow suppression.
Hayes, R (15549710) +1 more
core
British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson +8 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1999 From March 1996 to August 1997, a study was carried out in a malaria endemic area of the Brazilian Amazon region. In vivo sensitivity evaluation to antimalarial drugs was performed in 129 patients.
Crispim Cerutti Junior +7 more
doaj +1 more source
Birth Defects Research, Volume 118, Issue 10, October 2026.ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim +9 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 10, October 2026.ABSTRACT Plasmodium vivax (P. vivax) malaria, once regarded as a comparatively benign infection, is increasingly recognized as a cause of severe, potentially life‐threatening multisystem disease. Concurrent secondary hemophagocytic lymphohistiocytosis (HLH), disseminated intravascular coagulation (DIC), and acute pancreatitis complicating P.
Tasnim Nafian +5 more
wiley +1 more source
The estimation of quinine in quinine wine, tinctures, &c. [PDF]
The Analyst, 1881 n ...
openaire +1 more source