Results 61 to 70 of about 38,082 (231)

Pursing Quinoline-8-Sulfonamide derivatives for the identification of potent NPPs inhibitors: In silico molecular docking, molecular dynamics simulations and density field theory (DFT) studies

Results in Chemistry
Nucleotide pyrophosphatase/phosphodiesterase (NPP) enzymes belong to a broad category of ectonucleotidase enzymes. These NPPs are responsible for hydrolysis of extracellular nucleotides (ATP to AMP) and are therefore important regulators in the ...
Jamshed Iqbal, Talha Islam, Mariya al-Rashida, Abdul Hameed, Taseer Iftikhar, Julie Pelletier, Jean Sévigny, Salman Alrokayan, Maria Maqbool, Khurshid Ayub, Tajamul Hussain   +10 more
doaj   +1 more source

Aza‐Büchner–Curtius–Schlotterbeck Reaction Enables Selective Construction of Quaternary Carbon Centers

Angewandte Chemie International Edition, EarlyView.
We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer, Vincent George, Aryaman Pattanik, Gaia Carpentiero, Tereza Morcinková, Julia Rehbein, Burkhard König   +6 more
wiley   +1 more source

Crystal structure of ethyl 2-(3,5-difluorophenyl)quinoline-4-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C18H13F2NO2, the two rings of the quinoline system are fused almost coaxially, with a dihedral angle between their planes of 2.28 (8)°. The plane of the attached benzene ring is inclined to the plane of the quinoline system by 7.65 
V. M. Sunitha, S. Naveen, H. R. Manjunath, S. B. Benaka Prasad, V. Manivannan, N. K. Lokanath   +5 more
doaj   +1 more source

From classical to contemporary: A review on the synthesis and biological activities of quinoline and its derivatives [PDF]

Scripta Medica
Quinoline-derived analogues have considerable significant attention due to their wide range of pharmacological activities and promising therapeutic applications.
Kaur Harmanbir, Kaur Tejinder, Bhandari Divya Dhawal, Sharma Rajiv   +3 more
doaj   +1 more source

Crystalline Quinolinate Phosphoribosyltransferase

Journal of Biological Chemistry, 1965
Abstract Quinolinate phosphoribosyltransferase catalyzes the formation of nicotinic acid mononucleotide, carbon dioxide, and inorganic pyrophosphate from quinolinic acid and 5-phosphoribosyl 1-pyrophosphate. The enzyme has a molecular weight of 165,000 and can be irreversibly dissociated into inactive protein units with a molecular weight of 54,000 ...
P M, Packman, W B, Jakoby
openaire   +2 more sources

Design, Synthesis, and Characterization of Tautomeric Quinoline-4-Carboxylic Acid–Based Esters, Amides, and Fused Heterocycles

Journal of Chemistry
Quinoline-4-carboxylic acid derivatives are widely studied owing to their structural versatility and relevance in pharmaceutical sciences. In this study, 3-benzoyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid was synthesized via a solvent-free reaction ...
Derviş Gök
doaj   +1 more source

Structural modifications of quinoline-based antimalarial agents: Recent developments

Journal of Pharmacy and Bioallied Sciences, 2010
Antimalarial drugs constitute a major part of antiprotozoal drugs and have been in practice for a long time. Antimalarial agents generally belong to the class of quinoline which acts by interfering with heme metabolism. The recent increase in development
Sandhya Bawa, Suresh Kumar, Sushma Drabu, Rajiv Kumar   +3 more
doaj   +1 more source

Crystal structure of bis(2,2′-bipyridine)[N′-(quinolin-2-ylmethylidene)pyridine-2-carbohydrazide]ruthenium(II) bis(tetrafluoridoborate) dichloromethane trisolvate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, [Ru(C10H8N2)2(C16H12N4O)](BF4)2·3CH2Cl2, crystallizes with one complex dication, two BF4− counter-anions and three dichloromethane solvent molecules in the asymmetric unit.
Asami Mori, Takayoshi Suzuki, Kiyohiko Nakajima   +2 more
doaj   +1 more source

Benzimidazole-Quinoline Hybrids: Synthesis and Antimicrobial Properties

Pharmaceuticals
Background: Heterocyclic compounds are particularly important in medicinal chemistry. With a range of therapeutic uses, benzimidazoles and quinolines are both key heterocycles in medicinal chemistry.
Maria Marinescu
doaj   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source