Results 81 to 90 of about 56,164 (276)

Structural modifications of quinoline-based antimalarial agents: Recent developments

Journal of Pharmacy and Bioallied Sciences, 2010
Antimalarial drugs constitute a major part of antiprotozoal drugs and have been in practice for a long time. Antimalarial agents generally belong to the class of quinoline which acts by interfering with heme metabolism. The recent increase in development
Sandhya Bawa, Suresh Kumar, Sushma Drabu, Rajiv Kumar   +3 more
doaj   +1 more source

Studies of some Bio-active Heterocyclic Moieties [PDF]

, 2010
Not ...
Bhatt, Mehul P.
core  

Quinoline-thioureidopeptides: A new approach for the synthesis of quinoline-isothiocyanate and their peptide linkage

, 2009
We present an efficient synthetic route for quinoline condensed thioureidopeptidyl esters from corresponding isothiocyanate and amino acid esters. The utility of quinoline isothiocyanate as major building block for desired thioureidopeptides of quinoline
Sureshbabu, V.V., Hemantha, H.P., Bhojya Naik, H.S., Prakash Naik, H.R., Aravinda, T.   +4 more
core   +1 more source

Design, Synthesis, and Characterization of Tautomeric Quinoline-4-Carboxylic Acid–Based Esters, Amides, and Fused Heterocycles

Journal of Chemistry
Quinoline-4-carboxylic acid derivatives are widely studied owing to their structural versatility and relevance in pharmaceutical sciences. In this study, 3-benzoyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid was synthesized via a solvent-free reaction ...
Derviş Gök
doaj   +1 more source

Crystal structure of bis(2,2′-bipyridine)[N′-(quinolin-2-ylmethylidene)pyridine-2-carbohydrazide]ruthenium(II) bis(tetrafluoridoborate) dichloromethane trisolvate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, [Ru(C10H8N2)2(C16H12N4O)](BF4)2·3CH2Cl2, crystallizes with one complex dication, two BF4− counter-anions and three dichloromethane solvent molecules in the asymmetric unit.
Asami Mori, Takayoshi Suzuki, Kiyohiko Nakajima   +2 more
doaj   +1 more source

Crystalline Quinolinate Phosphoribosyltransferase

Journal of Biological Chemistry, 1965
Abstract Quinolinate phosphoribosyltransferase catalyzes the formation of nicotinic acid mononucleotide, carbon dioxide, and inorganic pyrophosphate from quinolinic acid and 5-phosphoribosyl 1-pyrophosphate. The enzyme has a molecular weight of 165,000 and can be irreversibly dissociated into inactive protein units with a molecular weight of 54,000 ...
P M, Packman, W B, Jakoby
openaire   +2 more sources

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source

Benzimidazole-Quinoline Hybrids: Synthesis and Antimicrobial Properties

Pharmaceuticals
Background: Heterocyclic compounds are particularly important in medicinal chemistry. With a range of therapeutic uses, benzimidazoles and quinolines are both key heterocycles in medicinal chemistry.
Maria Marinescu
doaj   +1 more source

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source