Results 171 to 180 of about 26,162 (241)

Photocatalytic Cross‐Coupling of Phenols and Heteroaryl Halides With Machine Learning‐Guided Reaction Prediction

Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.
Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson, Alice Wu, Kalyana B. Duggal, Madeline E. Rotella, Marisa C. Kozlowski   +4 more
wiley   +2 more sources

Visible-light-enabled excited-state dearomatization reactions. [PDF]

Sci Adv
Li M, Cheng YZ, You SL.
europepmc   +1 more source

Efficient Machine Learning Prediction of Solvent‐Dependent 1H$$ {}^1\mathrm{H} $$ NMR Chemical Shifts in Zinc Complexes

Journal of Computational Chemistry, Volume 47, Issue 10, 15 April 2026.
Machine learning approach (ML) for rapid and accurate prediction of 1H‐NMR shifts in zinc complexes validated against experimental NMR data across multiple solvent environments. ABSTRACT Accurate prediction of NMR chemical shifts in transition metal complexes remains challenging due to the wide range of coordination environments and complex electronic ...
Jyothika R. Pillay, Michael Ringleb, Alexander Croy, Stefan Zechel, Ulrich S. Schubert, Stefanie Gräfe   +5 more
wiley   +1 more source

Comprehensive methodologies for synthesizing tricyclic fused pyrimidoquinolines of biological relevance: a review. [PDF]

RSC Adv
Mekheimer RA, Allam SMR, Al-Sheikh MA, Medrasi HY, Abd-Elmonem M, Sadek KU.   +5 more
europepmc   +1 more source

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

Microwave-Assisted Organic Syntheses in Deep Eutectic Solvents: A Win-Win Association for Sustainable Chemistry. [PDF]

ChemistryOpen
Delaye PO, Salami C, Thiery E.
europepmc   +1 more source

The production of isoquinoline alkaloids by plant sell cultures [PDF]

, 1985
Philipson, John D., Rüffer, Martina
core   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

The quinoline framework and related scaffolds in natural products with anti-<i>Leishmania</i> properties. [PDF]

Front Chem
Yaluff G, Herrera L, Rolón MS, Vega C, Cerecetto H.   +4 more
europepmc   +1 more source

Unlocking the Phosphoric Acid Catalyzed Asymmetric Transfer Hydrogenation of 2-Alkenyl Quinolines for Efficient Flow Synthesis of Hancock Alkaloids. [PDF]

Org Lett
Nagy BS, Maestro A, Pericàs MA, Kappe CO, Ötvös SB.   +4 more
europepmc   +1 more source