Results 151 to 160 of about 12,837 (198)
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ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
R. D. Larsen, D. Cai
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AbstractFor Abstract see ChemInform Abstract in Full Text.
R. D. Larsen, D. Cai
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Comparative mutagenesis of quinolines
Mutation Research/Reviews in Genetic Toxicology, 1977Abstract Quinoline, 8-hydroxyquinoline, 8-nitroquinoline, and 8-aminoquinoline are mutagenic in Salmonella when assayed by histidine reversion. Metabolic activation is required for the maximal effect. Frameshift mutagenesis appears to be the mechanism with 8-nitro- and 8-aminoquinoline. Quinoline and 8-hydroxyquinoline affect only the sensitive TA100
J L, Epler +5 more
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Norfloxacin: A Quinoline Antibiotic
Drug Intelligence & Clinical Pharmacy, 1986Norfloxacin is a quinoline (quinolinecarboxylic acid) that should prove successful in treating infections that currently require hospitalization and intravenous antibiotics. Although a nalidixic acid derivative, it possesses greater antibacterial activity against gram-positive and gram-negative bacteria.
D A, Marble, J A, Bosso
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Quinoline: Synthesis to Application
Medicinal Chemistry, 2023Abstract: This review aims to provide a comprehensive report on the quinoline ring with respect to its synthesis, reactivity, and therapeutic values. The reactivity of quinoline for the metal, electrophile, and other reactive counterparts defines the shape of the quinoline pharmacophore, which is an important part of this report; moreover, its ...
Priyank Purohit +3 more
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Current Medicinal Chemistry, 2010
Although the assortment of antifungal drugs is broad, the most commonly used agents have major drawbacks. Toxicity, serious side effects or the emergence of drug resistance are amongst them. New drugs and drug candidates under clinical trials do not guarantee better pharmacological parameters. These new medicines may appear effective; however; they may
R, Musiol +3 more
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Although the assortment of antifungal drugs is broad, the most commonly used agents have major drawbacks. Toxicity, serious side effects or the emergence of drug resistance are amongst them. New drugs and drug candidates under clinical trials do not guarantee better pharmacological parameters. These new medicines may appear effective; however; they may
R, Musiol +3 more
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Effect of quinolinate on aminotransferases
Archives of Biochemistry and Biophysics, 1976Abstract Quinolinate inhibits several aminotransferases (ornithine, alanine, and aspartate). However, it is considerably more potent as an inhibitor of liver and heart cytoplasmic aspartate aminotransferase. It is a much less potent inhibitor of mitochondrial aspartate aminotransferases.
S L, Hsu, L A, Fahien
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Quinoline-Annulated Porphyrins
Organic Letters, 2011Porphyrin-2,3-dione mono- and dioximes were used as starting materials for the efficient syntheses of mono- and bis-quinoline-annulated porphyrins and their corresponding N-oxides. Owing to an extended π-system, these novel porphyrinoid chromophores show significantly red-shifted UV-vis spectra compared to the parent porphyrins.
Joshua, Akhigbe +2 more
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SEPARATION OF QUINOLINE AND ISO-QUINOLINE BY DISSOCIATION EXTRACTION
Solvent Extraction and Ion Exchange, 1995ABSTRACT The separation of quinoline and iso-quinotine is studied using dissociation extraction. The effect of various parameters e.g. concentration, isomer ratio and solvents is presented. A universally applied equation for the calculation of separation factor has been used and found to require modification by inclusion of activity coefficients for ...
M. M. Anwar, A. S. Arif, D. W. Pritchard
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Friedländer quinoline synthesis
2009Also known as the Friedlander condensation, it combines an α-amino aldehyde or ketone with another aldehyde or ketone with at least one methylene α adjacent to the carbonyl to furnish a substituted quinoline. The reaction can be promoted by either acid, base, or heat.
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