Results 151 to 160 of about 19,883 (275)

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha, Mandapalli Sreeshitha, Shaik Farheen Banu, Kamala Prasad Vasikarla, Satyanarayana Swamy Vyshnava, Mukhriddin Makhkamov, Parthiban Marimuthu, Jamoliddin Razzokov, Aminul Islam, Peddiahgari Vasu Govardhana Reddy   +9 more
wiley   +1 more source

Complexation of Divalent Metals by Natural Furoquinoline Alkaloids: An Electrospray Mass Spectrometry and DFT Study. [PDF]

Rapid Commun Mass Spectrom
Valdez MB, Palermo JA, D'Jonsiles F, Cabrera GM, Siless GE.   +4 more
europepmc   +1 more source

Strain and Chirality: Catalytic Asymmetric Synthesis of Planar Chiral [2.2]Paracyclophanes

ChemistryEurope, Volume 4, Issue 11, November 2026.
Catalytic asymmetric synthesis is transforming access to planar‐chiral [2.2]paracyclophanes. This Review highlights recent advances in catalytic desymmetrization and asymmetric functionalization, emphasizing how catalyst design and PCP geometry govern reactivity and stereocontrol.
Daniel Alonso, Enrique Gómez‐Bengoa, Rosa López   +2 more
wiley   +1 more source

NiCo₂O₄/g-C₃N₄: an efficient heterogeneous photocatalyst for visible-light-driven tandem synthesis of 2,3-disubstituted quinolines. [PDF]

RSC Adv
Narasimman V, Madhumitha G.
europepmc   +1 more source

Salicylic Acid as a Food‐Derived Bioactive Constituent of Tiaoqi Daozhi Decoction: A Potential Functional Food Ingredient to Restoring Gut Barrier Function in Constipation‐Predominant IBS

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Tiaoqi Daozhi Decoction (TQDZD) is a classic formulation composed of eight medicine‐food homologous botanicals. UPLC‐MS/MS profiling identified 1962 non‐redundant compounds in its aqueous extract, predominantly phenolic acids and flavonoids, of which 107 metabolites were systemically bioavailable.
Min Duan, Lixia Huang, Yingyue Xu, Ya Huang, Xiaojun Yang   +4 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Three-Component Synthesis of 2‑Substituted Quinolines and Benzo[f]quinolines Using Tertiary Amines as the Vinyl Source

A metal-free method for the construction of 2-substituted quinolines and benzo­[f]­quinolines from aromatic amines, aldehydes, and tertiary amines has been demonstrated. Cheap and readily available tertiary amines acted as the vinyl source.
Yanfeng Ma (1969450), Guojiang Mao (1777903), Fuhong Xiao (1470838), Guo-Jun Deng (1427659), Chunlan Zhou (766565)   +4 more
core   +1 more source

Reactions of Isomeric Triplet and Singlet Aryloxenium Cations in the Gas Phase

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
This study presents a detailed experimental and computational examination of the gas‐phase reactivity and the reactive sites of the triplet 2‐amino‐4‐pyridyloxenium cation. It also provides a direct comparison of this reactivity to that of the isomeric singlet 3‐amino‐4‐pyridyloxenium cation and 3‐amino‐2‐pyridyloxenium cation that have not been ...
Tuong V. Nguyen, Markus Rohdenburg, Jonas Warneke, John J. Nash, Hilkka I. Kenttämaa   +4 more
wiley   +1 more source

C3‑H Amination of Quinolines Enabled by a Tailored Aminating Agent. [PDF]

JACS Au
Xu YH, Li XZ, Wu H.
europepmc   +1 more source

Nucleophilic Aromatic Substitution in the Gas Phase

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
In this review, we highlight experimental studies of gas‐phase SNAr. Studying reactions in the gas phase provides invaluable information on intrinsic reactivity by eliminating the complications of solvent effects. Because SNAr is a fundamental reaction in chemical research and organic synthesis, understanding its underlying reactivity and mechanisms is
Daniel N. Hirsch, Damon J. Hinz, Jeehiun K. Lee   +2 more
wiley   +1 more source