Results 151 to 160 of about 26,162 (241)

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
We report a photoenzymatic hydroalkylation that enables streamlined, stereocontrolled access to aryl glutarimide precursors relevant to targeted protein degradation. Engineered flavin‐dependent “ene”‐reductases provide broad scope and high enantioselectivity through a distinct electron transfer–enantioselective proton transfer pathway.
Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H. Vasilev, Eric R. Welin, Yichen Tan, Shane M. McKenna, Megan A. Emmanuel, Todd K. Hyster   +9 more
wiley   +2 more sources

Global consensus on the management of melanin hyperpigmentation disorders

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 5, Page 760-772, May 2026.
A global Delphi consensus of 10 dermatology experts established evidence‐based recommendations for melanin hyperpigmentation disorders, providing unified classification, photoprotection guidance and treatment algorithms. This framework harmonizes terminology and supports individualized management across diverse skin types and health systems.
Thierry Passeron, Seemal R. Desai, Marwa Abdallah, Firas Al‐Niaimi, Ncoza Dlova, Pearl E. Grimes, Jorge Ocampo‐Candiani, Rashmi Sarkar, Leihong Flora Xiang, Helio Amante Miot   +9 more
wiley   +1 more source

Net Oxidative Photocatalytic Strategy toward the <i>o</i>-Trifluoroacetylation of <i>N</i>-Heteroarenes. [PDF]

Org Lett
Samony KL, Thullaprambil JZ, Nabi RN, Brunner KE, Kim DK.   +4 more
europepmc   +1 more source

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2826-2842, May 2026.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines. [PDF]

ChemMedChem
Álvaro BS, Mackenzie TA, Ramos MC, García A, Villarroel-Vicente C, Vila L, Tormo JR, Cortes D, Cabedo N.   +8 more
europepmc   +1 more source

Antiprotozoal activity of quinoline alkaloids isolated from Galipea longiflora, a bolivian plant used as a treatment for cutaneous leishmaniasis [PDF]

, 1994
Angelo Barrios, A., Bruneton, J., Cavé, A., Fournet, Alain, Hocquemiller, R., Munoz, V., Richomme, P., Roblot, F.   +7 more
core   +1 more source

Discovery of [1,2,4]triazolo[1,5‐a]pyrimidine‐Imatinib Hybrids With Selective Cytotoxic Activity: A Mechanistically Divergent Series From Direct BCR‐ABL1 Inhibition

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Discovery of imatinib–triazolopyrimidine hybrids with selective cytotoxicity and a mechanism distinct from classical BCR‐ABL1 inhibition. This bioisosteric strategy introduces a novel compounds, paving the way for innovative antileukemic therapies with differentiated profiles.
Stefany Castro Bazan Moura, Andressa Paula de Oliveira, Joao de Mello Rezende Neto, Rafael Ferreira Dantas, Floriano Paes Silva‐Jr, Luiz Claudio Pimentel, Mayara Salles do Nascimento Carvalho, Debora Inacio Leite, Daiane Vitoria da Silva, Monica Macedo Bastos, Nubia Boechat   +10 more
wiley   +1 more source

One-pot CuI/l-proline-catalysed multicomponent synthesis of pyrido[2',1':2,3]imidazo[4,5-<i>c</i>]quinoline derivatives from 2-(2-bromophenyl)imidazo[1,2-<i>a</i>]pyridines, NH₃ and DMSO under air. [PDF]

RSC Adv
Phuc BV, Thi Thuy D, Dao PA, Nguyen VL, Nguyen VH, Huy Nguyen H, Do DV, Nguyen H, Hung TQ, Dang TT.   +9 more
europepmc   +1 more source

Unveiling the Photophysical Properties of Indole‐Containing Boron Complexes: Exploring Intramolecular Charge Transfer Character, Tunable Emission, and Large Stokes Shifts

ChemPhysChem, Volume 27, Issue 8, 28 April 2026.
Indolyl‐imine–based NN complexes were synthesized and investigated to clarify how structural modification tunes intramolecular charge transfer (ICT), resulting in large Stokes shifts and tunable emission properties. Steady‐state and ultrafast spectroscopy, supported by density‐functional theory (DFT), showed that altering peripheral phenyl groups ...
Emrah Özcan, Valentyna Kuznetsova, Alina Kaliuzhna, Zehra Coşkun, Mehmet F. Saglam, Ibrahim F. Sengul, Fahri Alkan, Tomas Polivka, Bünyemin Çoşut   +8 more
wiley   +1 more source

Editorial: Quinoline as lead structures for the development of leishmanicidal agents. [PDF]

Front Chem
Romero AH, Benaim G.
europepmc   +1 more source