Results 211 to 220 of about 16,555 (256)
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Inhibition of quinolinate phosphoribosyl transferase by pyridine analogs of quinolinic acid
Biochemical and Biophysical Research Communications, 1988The enzyme quinolinate phosphoribosyl transferase was purified from ATCC strain 23269. An HPLC method was developed for the analysis of the product of the enzyme reaction, nicotinate mononucleotide. Steady state kinetics in the forward reaction demonstrated a sequential mechanism for the enzyme. In order to gain more information on the mechanism of the
L, Kalikin, K C, Calvo
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Boric acid catalyzed chemoselective reduction of quinolines
Organic & Biomolecular Chemistry, 2020Boric acid promoted transfer hydrogenation of substituted quinolines to synthetically versatile 1,2,3,4-tetrahydroquinolines (1,2,3,4-THQs) was described under mild reaction conditions using a Hantzsch ester as a mild organic hydrogen source.
Dipanjan Bhattacharyya +5 more
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Quinolinic Acid and Kynurenic Acid in the Mammalian Brain
1991Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
R, Schwarcz, F, Du
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Memantine prevents quinolinic acid-induced hippocampal damage
European Journal of Pharmacology, 1992Memantine, used as a drug for treatment of spasticity and other extrapyramidal disorders as well as dementia, was shown to prevent brain damage caused by the glutamate (N-methyl-D-aspartate, NMDA) receptor agonist, quinolinic acid. Studies were focused on the hippocampal formation which is known to be highly vulnerable to quinolinate.
G, Keilhoff, G, Wolf
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The quinolinic acid hypothesis in Huntington's chorea
Journal of the Neurological Sciences, 1990In the central nervous system and particularly in the striatum of patients with Huntington's disease (HD) a dramatic cell loss can be observed. Animal models of HD are based on intrastriatal injection of excitatory amino acids (EAAs). Stimulation of EAA receptors for a prolonged period of time degenerates the cells on which the EAA receptors are ...
R P, Bruyn, J C, Stoof
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Quinolinic acid in children with congenital hyperammonemia
Annals of Neurology, 1993AbstractLevels of the excitotoxin quinolinic acid (QUIN) were measured in the cerebrospinal fluid of infants and children with congenital hyperammonemia. Twofold to tenfold elevations of QUIN were found in 4 neonates in hyperammonemic coma (QUIN range, 250–990 nM; control mean, 110 ± 90 nM; p < 0.005).
M L, Batshaw +4 more
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Quinolinic Acid and Active Oxygens
1996Quinolinic acid (QA, pyridine-2,3-dicarboxylic acid) is an intermediate of the kynurenine pathway in the tryptophan metabolism, which has been detected in the central nervous system (Gal and Sherman, 1978; Speciale and Schwarcz, 1993), and behaves as an excitotoxin (Lapin, 1978; Schwarcz et al., 1983).
K. Goda +4 more
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Quinolinic acid: regional variations in neuronal sensitivity
Brain Research, 1983The excitatory action of quinolinic acid has been examined on neurons in different parts of the rat CNS. When applied by microiontophoresis quinolinic acid excited cells in the cerebral cortex, hippocampus and neostriatum, but even when applied from electrodes which produced responses in these areas, quinolinic acid was ineffective in the cerebellum ...
M N, Perkins, T W, Stone
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Quinolinic Acid: A Pathogen in Seizure Disorders?
1986The evidence for an involvement of QUIN in human seizure disorders is clearly circumstantial. Importantly, QUIN is not a classical neurotransmitter and may thus play only a negligible or no role at all in normal brain function (Foster et al., 1984). We have yet to understand if and how such a possibly inert metabolite may turn into a pathogen.
R, Schwarcz +4 more
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Derivatives Of Quinoline-3-carboxylic Acid And Benzo(f)quinoline-2- Carboxylic Acid.
1950PhD ; Pharmacology ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/182998/2/0002401 ...
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