Results 101 to 110 of about 3,523,720 (291)

Quinolone tolerance in Escherichia coli due to defects in the adenosine ribonucleotides de novo biosynthesis pathway

mLife, EarlyView.
Abstract Central carbon metabolism is thought to link reactive oxygen species (ROS) with antibiotic‐mediated bacterial death. During enrichment screening of Escherichia coli with the first‐generation quinolone oxolinic acid, unstable antibiotic‐tolerant mutants containing deficiencies in purB were obtained.
Weiwei Zhu, Yuejuan Nong, Jie Su, Jingwen Yang, Lina Ma, Yunxin Xue, Dai Wang, Jianjun Niu, Karl Drlica, Xilin Zhao   +9 more
wiley   +1 more source

Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.

PLoS ONE, 2018
Shigella represents one of the major diarrhea-inducing pathogens threatening public health, but its prevalence and antimicrobial resistance profile in Xinjiang Uygur Autonomous region, China, remains unclear.
Hongbo Liu, Binghua Zhu, Shaofu Qiu, Yidan Xia, Beibei Liang, Chaojie Yang, Nian Dong, Yongrui Li, Ying Xiang, Shan Wang, Jing Xie, Muti Mahe, Yansong Sun, Hongbin Song   +13 more
doaj   +1 more source

The inactivation of RNase G reduces the Stenotrophomonas maltophilia susceptibility to quinolones by triggering the heat shock response.

Frontiers in Microbiology, 2015
Quinolone resistance is usually due to mutations in the genes encoding bacterial topoisomerases. However different reports have shown that neither clinical quinolone resistant isolates nor in vitro obtained S.
Alejandra eBernardini, Fernando eCorona, Ricardo eDias, Maria Blanca Sanchez, Jose L Martinez   +4 more
doaj   +1 more source

Prevalence of mechanisms decreasing quinolone-susceptibility among Salmonella spp. clinical isolates [PDF]

, 2010
Fluoroquinolone treatment failure has been reported in patients with nalidixic acid-resistant Salmonella infections. Both chromosomal- and plasmid-mediated quinolone-resistance mechanisms have been described.
Amy D. Lunn, Anna Fàbrega, Javier Sánchez-Céspedes, Jordi Vila   +3 more
core   +2 more sources

Overlap of Antibiotic Resistant Campylobacter jejuni MLST Genotypes Isolated From Humans, Broiler Products, Dairy Cattle and Wild Birds in Lithuania [PDF]

, 2019
Antimicrobial resistance was determined for 341 thermophilic Campylobacter jejuni isolates obtained from human clinical cases (n = 101), broiler products (n = 98), dairy cattle (n = 41) and wild birds (n = 101) with known multilocus sequence types (MLST)
Aksomaitiene, Jurgita, Alter, Thomas, Malakauskas, Mindaugas, Novoslavskij, Aleksandr, Ramonaite, Sigita, Tamuleviciene, Egle   +5 more
core   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, EarlyView.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

Quinolone resistance in absence of selective pressure: the experience of a very remote community in the Amazon forest.

PLoS Neglected Tropical Diseases, 2012
BackgroundQuinolones are potent broad-spectrum bactericidal agents increasingly employed also in resource-limited countries. Resistance to quinolones is an increasing problem, known to be strongly associated with quinolone exposure.
Lucia Pallecchi, Alessandro Bartoloni, Eleonora Riccobono, Connie Fernandez, Antonia Mantella, Donata Magnelli, Dario Mannini, Marianne Strohmeyer, Filippo Bartalesi, Hugo Rodriguez, Eduardo Gotuzzo, Gian Maria Rossolini   +11 more
doaj   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Social interactions in the Burkholderia cepacia complex : biofilms and quorum sensing [PDF]

, 2010
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B.
Coenye, Tom
core   +2 more sources

A structured, behavioural science approach to the preparation of antimicrobial stewardship interventions for companion animal veterinarians

Veterinary Record, EarlyView.
Abstract Background A structured, behavioural science approach was adopted to develop antimicrobial stewardship interventions in UK first‐opinion companion animal veterinary practice. The objectives were to identify behavioural targets for intervention and to understand how practice contexts influence these behaviours.
Ben Walker, Dan O'Neill, Huw Stacey, Dave Brodbelt   +3 more
wiley   +1 more source