Results 121 to 130 of about 53,220 (228)

Total Synthesis and Antimalarial Studies of Caelestines A–C

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Total synthesis of caelestines A–C (alkaloids from the Australian ascidian, Aplidium caelestis) was accomplished, constituting the first synthesis of caelestines B and C. Caelestines A–C, with five other novel quinolones, were assessed against Plasmodium falciparum 3D7 and Dd2. Caelestine B was found to be a selective antimalarial alkaloid. Caelestines
Henry S. T. Smith, Aaron M. Lock, Vicky M. Avery, Rohan A. Davis   +3 more
wiley   +1 more source

Molecular Investigation of Quinolone Resistance of Quinolone Resistance-Determining Region in Streptococcus pneumoniae Strains Isolated from Iran Using Polymerase Chain Reaction–Restriction Fragment Length Polymorphism Method

, 2014
ObjectivesThe resistance of Streptococcus pneumoniae to the recently available antibiotic treatment has been a growing problem. The aim of the study was to determine the quinolone-resistant strains and detect the presence of mutations in the quinolone ...
Kargar, Mohammad, Doosti, Abbas, Moein Jahromi, Fataneh, Handali, Somayeh   +3 more
core   +1 more source

Molecular Identification of Aminoglycoside-Modifying Enzymes and Plasmid-Mediated Quinolone Resistance Genes among Klebsiella pneumoniae Clinical Isolates Recovered from Egyptian Patients

International Journal of Microbiology, 2017
Inappropriate use of antibiotics in clinical settings is thought to have led to the global emergence and spread of multidrug-resistant pathogens. The goal of this study was to investigate the prevalence of genes encoding aminoglycoside resistance and ...
Mohamed F. El-Badawy, Wael M. Tawakol, Shaymaa W. El-Far, Ibrahim A. Maghrabi, Saleh A. Al-Ghamdi, Moselhy S. Mansy, Mohammed S. Ashour, Mohamed M. Shohayeb   +7 more
doaj   +1 more source

Heterogeneous Fenton Degradation of Nalidixic Acid on Fe(II)‐Sorbed Maghemite, as Probed by In Situ Attenuated Total Reflectance‐Fourier Transform Infrared Spectroscopy

ChemPhysChem, Volume 27, Issue 11, 15 June 2026.
Using in situ attenuated total reflectancee‐Fourier transform infrared spectroscopy, we track how nalidixic acid adsorbs onto Fe(II)‐sorbed maghemite and undergoes reactive oxygen species (ROS)‐mediated degradation upon H2O2 addition. The spectra reveal key functional‐group transformations and ring opening, highlighting interfacial mechanisms of ...
Ana Carolina Schuh Frantz, Mbolantenaina Rakotomalala Robinson, Alberto Mezzetti, Sylvie Nélieu, Xavier Carrier, Guillaume Morin   +5 more
wiley   +1 more source

A structured, behavioural science approach to the preparation of antimicrobial stewardship interventions for companion animal veterinarians

Veterinary Record, Volume 198, Issue 12, Page e521-e532, 13–27 June 2026.
Abstract Background A structured, behavioural science approach was adopted to develop antimicrobial stewardship interventions in UK first‐opinion companion animal veterinary practice. The objectives were to identify behavioural targets for intervention and to understand how practice contexts influence these behaviours.
Ben Walker, Dan O'Neill, Huw Stacey, Dave Brodbelt   +3 more
wiley   +1 more source

Investigation of Plasmid-Mediated Quinolone Resistance in Escherichia coli Strains

, 2012
Quinolones are widely used antimicrobial agents, particularly for the treatment of infections caused by gram-negative bacilli such as E.coli. As a consequence, quinolone resistance has been increasing among this species in recent years.
AKTEPE, ORHAN CEM, Bicmen, Meral, Gulay, Zeynep, ÇETİNKOL, YELİZ, AŞIK, GÜLŞAH   +4 more
core  

Phenotypic screening for quinolone resistance in Escherichia coli

, 2019
Recent studies show that rectal colonization with low-level ciprofloxacin-resistant Escherichia coli (ciprofloxacin minimal inhibitory concentration (MIC) above the epidemiological cutoff point, but below the clinical breakpoint for resistance), i.e., in
Hanberger, Håkan, Hällgren, Anita, Dellgren, Linus,, Hällgren, Anita,, Forsberg, Jon, Dellgren, Linus, Claesson, Carina,, Forsberg, Jon,, Nilsson, Lennart E,, Claesson, Carina, Nilsson, Lennart E, Högdahl, Marie,, Högdahl, Marie, Hanberger, Håkan,   +13 more
core   +1 more source

Plasmid-Mediated Quinolone Resistance in Shigella flexneri Isolated From Macaques

, 2018
Non-human primates (NHPs) for biomedical research are commonly infected with Shigella spp. that can cause acute dysentery or chronic episodic diarrhea.
Mary M. Patterson, Mannion, Anthony J., Heather R. Martin, Anthony J. Mannion, James G. Fox, Martin, Heather R, Ellen M. Buckley, Dzink-Fox, JoAnn L., Alexis Garcia, Zeli Shen, Marini, Robert P, Patterson, Mary M, Jordan, Ellen Marie Buckley, Garcia, Alexis, JoAnn L. Dzink-Fox, Shen, Zeli, Robert P. Marini, Fox, James G   +17 more
core   +1 more source

Quinolone Resistance Reversion by Targeting the SOS Response

, 2017
Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia ...
E. Recacha, J. M. Rodríguez-Martínez, J. Rodriguez-Beltrán, Blazquez, J, J. Machuca, Recacha, E, Rodriguez-Martinez, J M, Pascual, A, J. Blázquez, Ramos-Güelfo, M, Machuca, J, F. Docobo-Pérez, Díaz de Alba, P, P. Díaz de Alba, Docobo-Perez, F, M. Ramos-Güelfo, A. Pascual, Rodriguez-Beltran, J   +17 more
core   +1 more source

Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal-Ion-Independent Drug–Enzyme Interactions

, 2016
Quinolones, which target gyrase and topoisomerase IV, are the most widely prescribed antibacterials worldwide. Unfortunately, their use is threatened by the increasing prevalence of target-mediated drug resistance.
Heidi A. Schwanz (1658641), Sylvia A. McPherson (1658638), Gangqin Li (1658632), Robert J. Kerns (1347510), Neil Osheroff (16602), Katie J. Aldred (1658635), Charles L. Turnbough (1867318)   +6 more
core   +1 more source