Results 191 to 200 of about 53,220 (228)

Resistance to quinolones

Pharmaceutisch Weekblad Scientific Edition, 1987
Resistance to quinolones is only due to mutations. The mechanism and the range of quinolones involved, depend on the locus of the chromosomal mutation e.g. a mutation in the gyr A locus is associated with resistance due to changes in the gyrase. Using high inocula in vitro, varying, but relatively low mutation rates of resistance to fluoroquinolones ...
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The Epidemiology of Bacterial Resistance to Quinolones

Drugs, 1993
The new fluoroquinolones have been in use for nearly 10 years in the treatment of community- and nosocomially-acquired infections. Resistant clones may be selected during therapy and disseminate if favourable epidemiological conditions prevail. Resistance to the fluoroquinolones is still rare in common pathogens with 97 to 100% of strains remaining ...
J F, Acar, T F, O'Brien, F W, Goldstein, R N, Jones   +3 more
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New quinolones and the impact on resistance

Drug Discovery Today, 2001
The changes in quinolone research have been fast and exciting over the past 5-7 years with the discovery and development of several new 8-methoxy quinolones. An additional factor is the design of the so-called 4th-generation quinolones that lack the C-6 fluorine, which might impact the development of quinolone resistance.
T J., Dougherty, D, Beaulieu, J F., Barrett   +2 more
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Mechanisms of Quinolone resistance

Journal of Infection and Chemotherapy, 1997
Quinolone resistance is induced by mutations on quinolone target enzymes such as gyrase and topo IV, and by mutations that prevent drug accumulation as a result of changes in outer membrane proteins and/or activation of drug-efflux pumps. Mutations on the target enzymes usually cause resistance to quinolones specifically, but mutations affecting drug ...
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Quinolone resistance in Neisseria gonorrhoeae

Current Infectious Disease Reports, 2001
Single-dose oral quinolones have been recommended for gonorrhea treatment since 1989. The antimicrobial resistance surveillance system has detected several outbreaks of quinolone-resistant gonococcal infections (QRNG), and sporadic treatment failures have been reported from high-incidence areas such as southeast Asia.
Janine R., Tompkins, Jonathan M., Zenilman   +1 more
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Mechanism of Action of and Resistance to Quinolones

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2001
A topoisomerase was identified as the bacterial target site for quinolone action in the late 1970s. Since that time, further study identified two bacterial topoisomerases, DNA gyrase and topoisomerase IV, as sites of antibacterial activity. DNA gyrase appears to be the primary quinolone target for gram‐negative bacteria.
D T, Bearden, L H, Danziger
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Quinolone Resistance: A Practical Perspective

Archives of Internal Medicine, 1993
The recent letter by Fish et al 1 discusses concern over the development of resistance to the fluoroquinolone antibiotics, especially in Staphylococcus aureus and Pseudomonas aeruginosa . 2,3 They suggest that resistance to fluoroquinolones should be reexamined in comparison with rates of emergence of resistance to other classes of antibiotics.
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Epidemiology of Quinolone Resistance

Drugs, 1995
Both nalidixic acid and fluoroquinolones are used widely in the Eastern hemisphere for a variety of infectious diseases. A surveillance programme for antibiotic resistance in common pathogens has been conducted in the Western Pacific Region of the World Health Organization since 1989.
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Quinolones and Multidrug-Resistant Tuberculosis

Chemotherapy, 1999
The prevalence of initial resistance of multidrug-resistant tuberculosis (MDR-TB) to at least isoniazid (INH) and rifampicin (RFP) in Thailand during the period 1993–1997 is reported; in this era, trends for INH + RFP + streptomycin (SM) and ethambutol (EMB), INH + RFP + SM or EMB and MDR-TB were stable. The prevalence of acquired MDR-TB is on a slight
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The induction of quinolone resistance in Campylobacter bacteria in broilers by quinolone treatment

Letters in Applied Microbiology, 1994
Nowadays Campylobacter spp. are recognized as an important cause of human diarrhoea. Campylobacteriosis is mainly a food-borne infection and products of animal origin, in The Netherlands especially poultry meat, play a major role in transmission4,6. Most human Campylobacter infections are self-limiting and do not need antimicrobial therapy. However, in
W. F. Jacobs-Reitsma, C. A. Kan, N. M. Bolder   +2 more
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