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Development of the quinolones. [PDF]
Journal of Antimicrobial Chemotherapy, 2003 Since their discovery in the early 1960s, the quinolone group of antibacterials has generated considerable clinical and scientific interest. Nalidixic acid, the first quinolone to be developed, was obtained as an impurity during the manufacture of quinine.
M. Andersson, A. Macgowan
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DNA Gyrase as a Target for Quinolones
Biomedicines, 2023 Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials. DNA gyrase is one of the primary targets of quinolones, broad-spectrum
Angela C Spencer, S. Panda
semanticscholar +1 more source
Biological Effects of Quinolones: A Family of Broad-Spectrum Antimicrobial Agents
Molecules, 2021 Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration combined with safety and few, yet rare, unwanted effects, have made the quinolones class of antimicrobials one of the most used in inpatients and outpatients ...
Ana R Millanao +4 more
semanticscholar +1 more source
Pharmaceutics, 2021 The evolution of the class of antibacterial quinolones includes the introduction in therapy of highly successful compounds. Although many representatives were withdrawn due to severe adverse reactions, a few representatives have proven their ...
Aura Rusu +4 more
semanticscholar +1 more source
Canadian Journal of Infectious Diseases and Medical Microbiology, 1992 R Gold
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Consumption of quinolones in the community, European Union/European Economic Area, 1997–2017
Journal of Antimicrobial Chemotherapy, 2021 Objectives Data on quinolone consumption in the community were collected from 30 EU/European Economic Area (EEA) countries over two decades. This article reviews temporal trends, seasonal variation, presence of change-points and changes in the ...
N. Adriaenssens +8 more
semanticscholar +1 more source
Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance
Molecules, 2020 Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments. FQs target the bacterial enzymes DNA gyrase and
Natassja G Bush +3 more
semanticscholar +1 more source
Inactivation of Quinolone by Feces [PDF]
Journal of Infectious Diseases, 1986 J. J. M. van Saene +2 more
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Pharmacy, 2019 Quinolones are the second most common antibiotic class associated with drug-induced allergic reactions, but data on quinolone allergy are scarce. This review article discusses the available evidence on quinolone allergy, including prevalence, risk factors, diagnosis, clinical manifestations, cross-reactivity, and management of allergic reactions ...
Edoabasi U. McGee +5 more
openaire +3 more sources
Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients. [PDF]
, 2012 Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of the type, number, and duration of drugs used ...
Alfredo Ponce-de-Leon +72 more
core +13 more sources