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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Bizid+3 more
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Quinones shuffling the CARDs [PDF]
Quinones are small secondary metabolites synthesized by a broad range of organisms. Perception of these aromatic molecules in plants involves membrane-bound LRR-RLKs to induce downstream cellular responses in plants such as calcium fluxes, specific gene expression and MAPK activation.
Max Körner, Peter Slaby, Markus Albert
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Immunomodulation by quinones [PDF]
The therapeutic application of quinones in areas other than oncology, such as in chronic inflammation, has been proposed. However, because of the adverse side-effects on the function and vitality of almost all investigated cell types the therapeutical margin is small.
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Mini-Reviews in Medicinal Chemistry, 2005
Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the ...
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Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the ...
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The synthesis of quinones [PDF]
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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2010
Quinone reductases are a large group of enzymes that catalyze the reduction of quinones. NQO1 and NQO2 are the major mammalian quinone reductases that catalyze the reduction of quinones to hydroquinones. Both NQO1 and NQO2 are FAD-containing homodimers with a similar catalytic mechanism and overlapping substrate specificities; however, major ...
D. Siegel, D. Ross
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Quinone reductases are a large group of enzymes that catalyze the reduction of quinones. NQO1 and NQO2 are the major mammalian quinone reductases that catalyze the reduction of quinones to hydroquinones. Both NQO1 and NQO2 are FAD-containing homodimers with a similar catalytic mechanism and overlapping substrate specificities; however, major ...
D. Siegel, D. Ross
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Photoredox Reactions of Quinones
Chemistry – A European Journal, 2018AbstractPhotoredox reactions of quinones are reviewed, that enable C−H bond oxidation at the vicinity of the excited quinone carbonyl and concomitant reduction of the quinone under photoirradiation. Mechanistic insights on the benzo‐, naphtho‐, and anthraquinones are discussed. Also the potential utilities in organic synthesis are described.
Yoshio Ando, Keisuke Suzuki
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Quinones as antimycobacterial agents
Bioorganic & Medicinal Chemistry, 2004Mycobacterium tuberculosis is a serious worldwide health threat, killing almost 3 million people per year. Other mycobacterial species, especially Mycobacterium avium, are emerging pathogens in the immunocompromised population, most notably AIDS patients. These nontuberculous mycobacteria (NTM) are ubiquitous in the environment, and naturally resistant
Violeta Chavez+6 more
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Chemical Modifications of Biopolymers by Quinones and Quinone Methides
Angewandte Chemie International Edition in English, 1989AbstractMany quinones and their precursors, which are transformed oxidatively into quinones and/or quinone methides, are important natural products. As secondary metabolites, they frequently possess antibiotic and cytotoxic activities, in addition to acting sometimes as pathogens. Several plants and animals, especially insects, use quinonoid substances
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Tocopheryl quinones and mitochondria
Molecular Nutrition & Food Research, 2010AbstractIn the past, the role of tocopherols and tocopheryl hydroquinones as antioxidants in mitochondria has been examined. However, structural properties of tocopherols and tocopheryl quinones (arrangement of polar/apolar moieties) have also been recognized as being crucial for the selective transport of RRR‐α‐congeners compared with other ...
Thomas Rosenau+4 more
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