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The Metabolism and Toxicity of Quinones, Quinonimines, Quinone Methides, and Quinone-Thioethers
Current Drug Metabolism, 2002Quinones are ubiquitous in nature and constitute an important class of naturally occurring compounds found in plants, fungi and bacteria. Human exposure to quinones therefore occurs via the diet, but also clinically or via airborne pollutants. For example, the quinones of polycyclic aromatic hydrocarbons are prevalent as environmental contaminants and ...
Douglas C. Jones, Terrence J. Monks
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1974
Abstract Two unusual menaquinones have been revealed during examination of Brevibacterium thiogenitalis and Brevibacterium vitarumen. Both microorganisms were found to contain menaquinones-8 (II-H2) and -9 (II-H2). The major quinone of the former was menaquinone-9 (II-H2) while that of the latter was menaquinone-8 (II-H2).
Yoshio Sugiyama +4 more
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Abstract Two unusual menaquinones have been revealed during examination of Brevibacterium thiogenitalis and Brevibacterium vitarumen. Both microorganisms were found to contain menaquinones-8 (II-H2) and -9 (II-H2). The major quinone of the former was menaquinone-9 (II-H2) while that of the latter was menaquinone-8 (II-H2).
Yoshio Sugiyama +4 more
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2004
Quinones are redox molecules widely present in nature. Coenzyme Q is a subsituted benzoquinone having a polyprenyl chain in the 6-position (decaprenyl- in humans). It is a hydrophobic molecule imbedded in the lipid bilayer of mitochondria and other membranes; in mitochondria it is a component of the electron transfer chain and of the oxidative ...
LENAZ, GIORGIO, GENOVA, MARIA LUISA
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Quinones are redox molecules widely present in nature. Coenzyme Q is a subsituted benzoquinone having a polyprenyl chain in the 6-position (decaprenyl- in humans). It is a hydrophobic molecule imbedded in the lipid bilayer of mitochondria and other membranes; in mitochondria it is a component of the electron transfer chain and of the oxidative ...
LENAZ, GIORGIO, GENOVA, MARIA LUISA
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Acta Crystallographica Section C Crystal Structure Communications, 1997 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Bizid +3 more
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Quinones shuffling the CARDs [PDF]
Nature Plants, 2020 Quinones are small secondary metabolites synthesized by a broad range of organisms. Perception of these aromatic molecules in plants involves membrane-bound LRR-RLKs to induce downstream cellular responses in plants such as calcium fluxes, specific gene expression and MAPK activation.
Max Körner, Peter Slaby, Markus Albert
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Immunomodulation by quinones [PDF]
Pharmaceutisch Weekblad Scientific Edition, 1991 The therapeutic application of quinones in areas other than oncology, such as in chronic inflammation, has been proposed. However, because of the adverse side-effects on the function and vitality of almost all investigated cell types the therapeutical margin is small.
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Mini-Reviews in Medicinal Chemistry, 2005
Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the ...
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Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the ...
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The synthesis of quinones [PDF]
Contemporary Organic Synthesis, 1996 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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2010
Quinone reductases are a large group of enzymes that catalyze the reduction of quinones. NQO1 and NQO2 are the major mammalian quinone reductases that catalyze the reduction of quinones to hydroquinones. Both NQO1 and NQO2 are FAD-containing homodimers with a similar catalytic mechanism and overlapping substrate specificities; however, major ...
D. Siegel, D. Ross
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Quinone reductases are a large group of enzymes that catalyze the reduction of quinones. NQO1 and NQO2 are the major mammalian quinone reductases that catalyze the reduction of quinones to hydroquinones. Both NQO1 and NQO2 are FAD-containing homodimers with a similar catalytic mechanism and overlapping substrate specificities; however, major ...
D. Siegel, D. Ross
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Photoredox Reactions of Quinones
Chemistry – A European Journal, 2018AbstractPhotoredox reactions of quinones are reviewed, that enable C−H bond oxidation at the vicinity of the excited quinone carbonyl and concomitant reduction of the quinone under photoirradiation. Mechanistic insights on the benzo‐, naphtho‐, and anthraquinones are discussed. Also the potential utilities in organic synthesis are described.
Yoshio Ando, Keisuke Suzuki
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