Defining the role of αC helix interactions in the activation of the integrin αI domain
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö +7 more
wiley +1 more source
This paper introduces the Sextuple Helix Innovation Model as an extension of the Quintuple Helix Innovation Model by Carayannis and Campbell. The epistemic perspective considers the understanding of generative AI (GenAI) as a sixth helix of knowledge ...
Lutz Peschke
doaj +1 more source
Cuscuta reflexa infection sites. Summary Cuscuta species are holoparasitic plants that penetrate host stems with haustoria, connect to the vasculature and exhaust water, nutrients and carbohydrates. Parasite seedlings possess only limited maternal reserves and the development of a vascular connection takes several days.
Maleen Hartenstein +10 more
wiley +1 more source
Greening Universities with Mode 3 and Quintuple Helix Model of Innovation-Production of Knowledge and Innovation in Knowledge-Based Economy, Botswana. [PDF]
Liyanage SIH, Netswera FG.
europepmc +1 more source
Accuracy of cone‐beam computed tomography in imaging the components of the periodontal phenotype
Abstract The components and dimensions of the periodontal and peri‐implant phenotype have a high relevance in contemporary dental research and should be taken into consideration in the decision‐making process in the management of a variety of clinical scenarios to optimize the outcomes of therapy.
Ralf Schulze +2 more
wiley +1 more source
The Role of Universities in Social Innovation Within Quadruple/Quintuple Helix Model: Practical Implications from Polish Experience. [PDF]
Morawska-Jancelewicz J.
europepmc +1 more source
Gender Equity, internationalization and quintuple helix:
As higher education institutions (HEIs) seek to align with Sustainable Development Goals (SDGs), integrating diversity, equity, and inclusion (DEI) into internationalization strategies has become increasingly central. In this study, we analyze 209 university strategic plans, 86 from Japan (2022–2027) and 123 from Türkiye (2019–2023), to examine how ...
Elif Bengü +3 more
openaire +1 more source
Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar +10 more
wiley +1 more source
Smart Environments and Techno-centric and Human-Centric Innovations for Industry and Society 5.0: A Quintuple Helix Innovation System View Towards Smart, Sustainable, and Inclusive Solutions. [PDF]
Carayannis EG +3 more
europepmc +1 more source
ABSTRACT Rationale Isotope ratio mass spectrometry (IRMS) and proton nuclear magnetic resonance (1H NMR) spectroscopy are independent techniques for determining the isotope ratio R(13C/12C) in organic compounds. However, the lack of suitable reference materials has limited intercalibration of results from these methods.
David W. Hoffman +5 more
wiley +1 more source

