Results 141 to 150 of about 1,525 (166)

Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists

Journal of Medicinal Chemistry, 1988
All of the optical isomers of the muscarinic antagonists 3-(1-azabicyclo[2.2.2]octyl) alpha-hydroxy-alpha,alpha-diphenylacetate (3-quinuclidinyl benzilate, QNB, 1) 3-(1-azabicyclo[2.2.2]octyl) xanthene-9-carboxylate (3-quinuclidinyl xanthene-9-carboxylate, QNX, 2), and 3-(1-azabicyclo[2.2.2]ocytl) alpha-hydroxy-alpha-phenylpropionate (3-quinuclidinyl ...
W J, Rzeszotarski, D W, McPherson, J W, Ferkany, W J, Kinnier, L, Noronha-Blob, A, Kirkien-Rzeszotarski   +5 more
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Cholinergic antagonist 3-quinuclidinyl benzilate – Impact on learning and memory in Wistar rats

Behavioural Brain Research, 2014
3-Quinuclidinyl benzilate (QNB) represents a non-selective, competitive antagonist of cholinergic receptors, which has been previously used to generate cognitive deficits in animal models of neurodegenerative disorders. The aim of this study was evaluation of QNB potency for creation of cognitive impairment during the acquisition, consolidation and ...
Jan, Misik, Jan, Vanek, Kamil, Musilek, Jiri, Kassa   +3 more
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[The specific binding of dihydroalprenolol and quinuclidinyl benzilate with myocardial lysosomes].

Farmakologiia i toksikologiia, 1990
The binding of 3H-dihydroalprenolol and 3H-quinuclidinyl benzylate to lysosomes of the rat ventricular myocardium vas studied. More than one type of specific binding sites of dihydroalprenolol and quinuclidinyl benzylate at the rat myocardium lysosomes were found.
N A, Sysoliatina, V I, Tomilenko
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Antibodies to 3-quinuclidinyl benzilate

Pharmaceutical Chemistry Journal, 1995
S. S. Krylov, T. A. Dezhinova
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Structure-binding relationship of quinuclidinyl benzilate analogs on N4TG1 neuroblastoma muscarinic receptors

Neurochemical Research, 1988
By Scatchard plot analysis of [3H]QNB (quinuclidinyl benzilate) binding, there are 2 x 10(5) muscarinic sites/cell with a KD about 10 nM in N4TG1 neuroblastoma cells. We have now examined a group of compounds structurally related to aprophen and QNB for their ability to compete with the binding of QNB to the muscarini receptor.
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Reduced binding of (3H)-Quinuclidinyl benzilate associated with chronically low acetylcholinesterase activity

Life Sciences, 1979
Abstract ( 3 H)-Quinuclidinyl benzilate (QNB) binding was examined in the cortex, striatum and hippocampus of rats repeatedly exposed to the anticholinesterase, diisopropyl fluorophosphate (DFP). Compared to vehicle-treated controls, a reduction in maximal binding of 25–30% was observed in these brain regions.
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The crystal and molecular structure of quinuclidinyl benzilate hydrobromide

Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, 1969
A, Meyerhöffer, D, Carlström
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Binding of [3H]quinuclidinyl benzilate to intestinal mucus

Biochemical Pharmacology, 1982
Thomas J. Rimele, Timothy S. Gaginella
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BZ (3-Quinuclidinyl Benzilate)

2014
R.E. Jabbour, H. Salem
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Psychotomimetic agent BZ (3-quinuclidinyl benzilate)

2020
Josef Fusek, Alzbeta Dlabkova, Jan Misik
openaire   +1 more source