Results 91 to 100 of about 7,972 (218)

DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. [PDF]

, 2014
Loss-of-function mutations in DJ-1 (PARK7) gene account for about 1% of all familial Parkinson's disease (PD). While its physiological function(s) are not completely clear, DJ-1 protects neurons against oxidative stress in both in vitro and in vivo ...
Aleyasin, Hossein, Bourquard, Noam, Callaghan, Steve, Figeys, Daniel, Huang, En, Irrcher, Isabella, Kim, Raymond H, Mak, Tak W, Park, David S, Parsanejad, Mohammad, Qu, Dianbo, Reddy, Srinivasa T, Rousseaux, Maxime WC, Slack, Ruth S, Vaillant, Dominique C, Zhang, Yi   +15 more
core   +2 more sources

Sustainable Photoinduced Frontal Polymerization of Acrylic Resins Reinforced by Biofillers

Polymer Composites, Volume 47, Issue 9, Page 8525-8535, 10 May 2026.
Top left: Chemical structures of the monomers and initiators used. Top right: Effect of monomer ratios on frontal velocity. Bottom left: Schematic overview of the PIFP process as the reaction front moves within the mold. Bottom right: Application of PIFP for wood repair.
Huseyin Mirac Dizman, Alessandra Vitale, Roberta Bongiovanni   +2 more
wiley   +1 more source

Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule [PDF]

, 2015
In Pseudomonas aeruginosa, quorum sensing (QS) regulates the production of secondary metabolites, many of which are antimicrobials that impact on polymicrobial community composition.
Birmes, Franziska S., Chan, Kok Gan, Chhabra, Siri Ram, Cámara, Miguel, Fetzner, Susanne, Halliday, Nigel, Heeb, Stephan, Müller, Christine, Soh, Eliza Ye-Chen, Williams, Paul   +9 more
core   +2 more sources

High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
We conducted a high‐throughput screen of 2747 FDA‐approved drugs to identify inhibitors of pyroptosis. We found that CeeNU significantly repressed NLRP3‐dependent IL‐1β release and GSDMD pore‐forming complex. We identified that the arginine 335 amino acid of the NACHT domain of NLRP3 is the critical point for human NLRP3 and CeeNU interaction and ...
Sen‐Lin Ji, Peipei Chen, Huaiping Tang, Chao Zhou, Zihao Li, Yunshu Wang, Xiang Cao, Liwen Zhu, Xinyu Bao, Zhuo Liu, Yan Chen, Yun Xu   +11 more
wiley   +1 more source

Quorum Quenching Enzymes and Biofouling Control

Journal of Life Science, 2016
Bacterial cell to cell communication strategies called quorum sensing (QS) using small diffusible signaling molecules (auto-inducers) govern the expression of various genes dependent on their population density manner. As a consequence of synthesis and response to the signaling molecules, individual planktonic cells synchronized group behaviors to ...
Young Jae Jeon, Won-Geom Jeong, Hye-Sook Heo   +2 more
openaire   +2 more sources

Estrategias innovadoras de bioconservación en la industria alimentaria [PDF]

, 2019
Uno de los debates más significativos en el campo de la producción de alimentos es la creciente preocupación de los consumidores por seguir una alimentación más natural.
Barcenilla Canduela, Coral
core   +1 more source

Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials [PDF]

, 2018
This is a post-peer-review, pre-copyedit version of an article published in Applied microbiology and biotechnology The final authenticated version is available online at: http://dx.doi.org/10.1007/s00253-018-8776-0Drug resistance occurrence is a global ...
Bassegoda Puigdomenech, Arnau, Ivanova, Kristina Dimitrova, Ramon Portés, Eva, Tzanov, Tzanko   +3 more
core   +2 more sources

Tetrameric hotdog‐fold structure and catalytic mechanism of the SaPaaI thioesterase from Staphylococcus aureus

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Acyl‐CoA thioesterases hydrolyse thioester bonds to release free fatty acyl chains and coenzyme A (CoA), thereby regulating lipid metabolism, signaling, and membrane homeostasis. Here, we present the structural and functional characterization of the Paal‐like thioesterase SAV0944 (SaPaaI) from Staphylococcus aureus.
Yogesh Khandokar, Parul Srivastava, Renate H. M. Schwab, Ashish Sethi, Naveen Vankadari, Jade K. Forwood   +5 more
wiley   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, Volume 13, Issue 19, 2 April 2026.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

In vivo and In vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp. [PDF]

, 2017
The significance of polymicrobial infections is increasingly being recognized especially in a biofilm context wherein multiple bacterial species—including both potential pathogens and members of the commensal flora—communicate, cooperate, and compete ...
An Hotterbeekx, Herman Goossens, Samir Kumar-Singh, Surbhi Malhotra-Kumar   +3 more
core   +1 more source