Quorum sensing and self-quorum quenching in the intracellular pathogen Brucellamelitensis. [PDF]
PLoS ONE, 2013 Brucella quorum sensing has been described as an important regulatory system controlling crucial virulence determinants such as the VirB type IV secretion system and the flagellar genes.
Matthieu Terwagne +5 more
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Breaking down bacterial communication: a review of quorum quenching agents
Future Journal of Pharmaceutical Sciences, 2023 Background Bacterial cells communicate via small extracellular molecules that facilitate gene expression which is dependent on cell density and this mechanism is known as Quorum Sensing (QS).
Tresa Boban, Sahaya Nadar, Savita Tauro
doaj +2 more sources
Synergistic Antimicrobial Action of Lactoferrin-Derived Peptides and Quorum Quenching Enzymes. [PDF]
Int J Mol Sci, 2023 Combined use of various antimicrobial peptides (AMPs) with enzymes that hydrolyze the signaling molecules of the resistance mechanism of various microorganisms, quorum sensing (QS), to obtain effective antimicrobials is one of the leading approaches in ...
Aslanli A +3 more
europepmc +2 more sources
Pharmacoinformatics-Based Approach for Uncovering the Quorum-Quenching Activity of Phytocompounds against the Oral Pathogen, Streptococcus mutans. [PDF]
Molecules, 2023 Streptococcus mutans, a gram-positive oral pathogen, is the primary causative agent of dental caries. Biofilm formation, a critical characteristic of S. mutans, is regulated by quorum sensing (QS).
Marimuthu SCV +10 more
europepmc +2 more sources
RdmA Is a Key Regulator in Autoinduction of DSF Quorum Quenching in Pseudomonas nitroreducens HS-18 [PDF]
mBio, 2023 Diffusible signal factor (DSF) represents a family of widely conserved quorum-sensing (QS) signals which regulate virulence factor production and pathogenicity in numerous Gram-negative bacterial pathogens.
Huishan Wang +5 more
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Computational and Structural Biotechnology Journal, 2021 Acyl-homoserine lactone (AHL) is the most studied autoinducer in gram-negative bacteria controlling infections of various pathogens. Quenching of AHL signaling by inhibiting AHL synthesis or AHL-receptor binding via small molecular chemicals or ...
Jinxing Liao +8 more
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PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Pseudomonas aeruginosa is the predominant pathogen in pulmonary infections associated with cystic fibrosis. Quorum sensing (QS) systems regulate the production of virulence factors and play an important role in the establishment of successful P ...
Putri D. Utari +3 more
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Extract from phyllosphere bacteria with antibiofilm and quorum quenching activity to control several fish pathogenic bacteria [PDF]
BMC Research Notes, 2021 Objective The objective of this research were to screen quorum quenching activity compound from phyllosphere bacteria as well as antibiofilm activity against several fish pathogen bacteria such as Aeromonas hydrophila, Streptococcus agalactiae, and ...
Olivia Nathalia +1 more
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Gentamicin Augments the Quorum Quenching Potential of Cinnamaldehyde In Vitro and Protects Caenorhabditis elegans From Pseudomonas aeruginosa Infection. [PDF]
Front Cell Infect Microbiol, 2022 The quorum sensing (QS) circuitry of Pseudomonas aeruginosa represents an attractive target to attenuate bacterial virulence and antibiotic resistance.
Chadha J +4 more
europepmc +2 more sources
Quorum Quenching Agents: Resources for Antivirulence Therapy [PDF]
Marine Drugs, 2014 The continuing emergence of antibiotic-resistant pathogens is a concern to human health and highlights the urgent need for the development of alternative therapeutic strategies.
Kaihao Tang, Xiao-Hua Zhang
doaj +4 more sources