Results 71 to 80 of about 288,709 (262)

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Quorum quenching quandary: resistance to antivirulence compounds [PDF]

The ISME Journal, 2011
Abstract Quorum sensing (QS) is the regulation of gene expression in response to the concentration of small signal molecules, and its inactivation has been suggested to have great potential to attenuate microbial virulence. It is assumed that unlike antimicrobials, inhibition of QS should cause less Darwinian selection pressure for ...
Toshinari, Maeda, Rodolfo, García-Contreras, Mingming, Pu, Lili, Sheng, Luis Rene, Garcia, Maria, Tomás, Thomas K, Wood   +6 more
openaire   +2 more sources

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Extract from phyllosphere bacteria with antibiofilm and quorum quenching activity to control several fish pathogenic bacteria

BMC Research Notes, 2021
Objective The objective of this research were to screen quorum quenching activity compound from phyllosphere bacteria as well as antibiofilm activity against several fish pathogen bacteria such as Aeromonas hydrophila, Streptococcus agalactiae, and ...
Olivia Nathalia, Diana Elizabeth Waturangi   +1 more
doaj   +1 more source

Incorporation of MoO3 Nanoparticles Into Polypropylene Fibers via Melt Spinning: Investigation of Mechanical, Thermal, and Chromic Properties

Journal of Applied Polymer Science, EarlyView.
Pure PP and PP/MoO3 filaments produced by melt spinning. ABSTRACT Polypropylene (PP) composite fibers containing 0.10, 0.20, and 0.50 wt% molybdenum oxide (MoO3) nanoparticles were produced via melt spinning. In the present study, the effect of this addition on the mechanical, thermal, and chromic properties of the fibers was investigated.
Raphael Borges Magalhães Bergamini, Maria Inês Bruno Tavares, Camila Vicente de Farias, Fabiane Gomes de Oliveira, Karla Mayara Arguelles Simões, Diego de Holanda Saboya Souza   +5 more
wiley   +1 more source

Phytoplankton Tune Local pH to Actively Modulate Circadian Gravitactic Behavior

Advanced Physics Research, EarlyView.
Diel vertical migration hides an unexpected twist: Phytoplankton quietly engineer their local pH landscape, splitting into behaviorally distinct sub‐groups which stay separated even in identical conditions. Circadian pH changes, occuring over the course of a day, reshape their gravitactic behavior and physiological functions in ways scientists have ...
Arkajyoti Ghoshal, Soumitree Mishra, Jayabrata Dhar, Hans‐Peter Grossart, Anupam Sengupta   +4 more
wiley   +1 more source

Engineered Probiotics: The Next‐Generation Therapeutics to Combat Antibiotic‐Resistant Bacterial Infections

Food Frontiers, EarlyView.
Engineered probiotics secretes fusion proteins which potentially neutralized the toxins secreted by other microbial communities. ABSTRACT On a global scale, the escalating burden of infectious diseases, predominantly attributed to bacterial pathogens, especially drug‐resistant strains, has progressed into a critical concern for clinical management and ...
Indu Singh, Raz Abdulqadir, Indira Kumari Verma, Yashika Awasthi, Arun Ratn, Juhi Sharma, Manmeet Rawat, Megh Singh Dhakad, Jasbir Dalal, Yash Gupta, Bhisham Narayan Singh, Divakar Sharma   +11 more
wiley   +1 more source

Quorum Quenching in Culturable Phyllosphere Bacteria from Tobacco [PDF]

International Journal of Molecular Sciences, 2013
Many Gram-negative plant pathogenic bacteria employ a N-acylhomoserine lactone (AHL)-based quorum sensing (QS) system to regulate their virulence traits. A sustainable biocontrol strategy has been developed using quorum quenching (QQ) bacteria to interfere with QS and protect plants from pathogens. Here, the prevalence and the diversity of QQ strains
Ma, Anzhou, Lv, Di, Zhuang, Xuliang, Zhuang, Guoqiang   +3 more
openaire   +2 more sources

Purification and Structural Analysis of QS-inhibiting Compounds from Staphylococcus delphini

Bio-Protocol, 2014
The knowledge that many pathogens rely on cell-to-cell communication mechanisms known as quorum sensing, opens a new disease control strategy: quorum quenching.
Ya-Yun Chu, Mulugeta Nega, Friedrich Götz   +2 more
doaj   +1 more source

Interference of Quorum Sensing by Delftia sp. VM4 Depends on the Activity of a Novel N-Acylhomoserine Lactone-Acylase. [PDF]

PLoS ONE, 2015
Turf soil bacterial isolate Delftia sp. VM4 can degrade exogenous N-acyl homoserine lactone (AHL), hence it effectively attenuates the virulence of bacterial soft rot pathogen Pectobacterium carotovorum subsp.
Vimal B Maisuria, Anuradha S Nerurkar
doaj   +1 more source