Results 141 to 150 of about 640,932 (312)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A firm-level dataset for analyzing entry, exit, employment and R&D expenditures in the UK: 1997-2012. [PDF]

Data Brief, 2016
Ugur M, Trushin E, Solomon E.
europepmc   +1 more source

R&D and Employment: Some Evidence from European Microdata [PDF]

After discussing theory regarding the consequences of technological change on employment and surveying previous microeconometric literature, our aim with this paper is to test the possible job creation effect of business R&D expenditures, using a unique ...
Bogliacino, Francesco, Piva, Mariacristina, Vivarelli, Marco   +2 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Endogenous R&D Spillovers and Industrial Research Productivity [PDF]

This paper explores the implications of a simple model of learning and innovation by firms. In this model R&D spillovers are partly determined by firms, rather than by the given economic environment.
James D. Adams
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Is Investment in Agricultural Research a Good Substitute for Price Support in U.S. Cotton? [PDF]

This article examines the effects of R&D on cotton yield and relationship between R&D and commodity support programs. The results indicate that yield elasticities with respect to cotton R&D is around 0.2-0.5 based on different regions.
Hudson, Darren, Pan, Suwen, Wang, Changgang   +2 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Tax Exemptions and R;D Expenditures in Iran Saeed Dorokhshi Moghaddam [PDF]

پژوهشهای اقتصادی
Aim and Introduction The belief that innovation is a crucial factor in driving economic growth has led governments worldwide to increase investment in research and development (R&D).
Saeed Dorokhshi Moghaddam, Bahram Sahabi, Hassan Heydari, Sajad Barkhordari   +3 more
doaj  

Determinants of Firm R&D: Evidence from Swedish Firm Level Data [PDF]

This paper analyses determinants of firm R&D and if predictions from the model of creative destruction is supported by data using matched employer-employee longitudinal data on the Swedish manufacturing industry.
Gustavsson, Patrik, Poldahl, Andreas
core