Results 121 to 130 of about 56,943 (309)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Does history matter for the relationship between R&D, Innovation and Productivity? [PDF]
This paper analyzes the relationship between R&D expenditures, innovation and productivity growth, taking into account the possibility of persistence in firms’ behaviour. We study this relationship for a sample of Spanish manufacturing firms between 1990
Lourdes Moreno, Elena Huergo
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
How Has the Portuguese Innovation Capability Evolved? Estimating a Time Series of the Stock of Technological Knowledge, 1960-2001 [PDF]
The importance of promoting innovation has been elevated up to a status of official standard since the Lisbon European Summit in 2000. Here research and development (R&D) was singled out as an essential element of the foundation on which innovation could
Aurora A. C. Teixeira
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Innovation performance of EU countries in context of R&D: R&D trap risk in Slovakia?
Journal of Innovation and EntrepreneurshipExpenditures in research and development (R&D) and their transformation in innovations are unanimously considered in the academic literature to be one of the key drivers of sustainable economic growth, total factor productivity, as well as the ...
Katarína Belanová +2 more
doaj +1 more source
The spatial dimension of the R&D expenditures in the Belgian enterprise sector [PDF]
Brussels economic review, 2002 info:eu-repo/semantics ...
Spithoven, André, Teirlinck, Peter
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
R&D and Productivity Growth: A Review of the Literature [PDF]
This paper reviews the literature on R&D to provide guidelines for recent efforts to include R&D in the national income accounts. The main conclusions are: 1. Measures of R&D as an asset held by a particular owner must be complemented by estimates of the
Leo Sveikauskas
core