Results 111 to 120 of about 24,660,605 (261)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Innovation performance of EU countries in context of R&D: R&D trap risk in Slovakia?
Journal of Innovation and EntrepreneurshipExpenditures in research and development (R&D) and their transformation in innovations are unanimously considered in the academic literature to be one of the key drivers of sustainable economic growth, total factor productivity, as well as the ...
Katarína Belanová +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
R&D in Europe: Expenditures across Sectors, Regions and Firm Sizes. CEPS Paperbacks. February 2009 [PDF]
, 2009 Europe’s growth outlook has weakened notably in the wake of the global financial crisis, and policy-makers are understandably preoccupied with achieving a near-term rebound.
Uppenberg, Kristian
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
In March 2000, the European Union’s Lisbon Agenda identified the low level of R&D as an important reason for Europe’s lacking economic growth. Seven years later, innovation still has the full attention of policy makers around Europe.
Sabine Visser
core
Revista Ambiente ContábilPurpose: To analyze and compare the accounting information disclosure level on technological Research & Development (R&D) expenditures in accounting reports filed in Brazil and the United States by publicly traded Brazilian companies from different ...
Marco Aurélio Goulart Canongia +1 more
doaj +1 more source
A firm-level dataset for analyzing entry, exit, employment and R&D expenditures in the UK: 1997-2012. [PDF]
Data Brief, 2016 Ugur M, Trushin E, Solomon E.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source