The Determinants of Pharmaceutical R&D Expenditures: Evidence from Japan [PDF]
During the past 20 years, the world pharmaceutical industry has experienced a dramatic increase in R&D intensity. We apply and extend a model developed by Grabowski and Vernon (2000) with a pooled data sample of the 15 publicly listed Japanese drug firms
Roediger-Schluga, Thomas +1 more
core
Effects of the R and D tax credit on energy R and D expenditures: an econometric analysis
, 1985 Objective of the study was to estimate the effects on industrial energy research and development (R and D) expenditures of the R and D Tax Credit component of the Economic Recovery Tax Act of 1981. Two tasks were performed.
Moe, R. J. +3 more
core +1 more source
Heart of Darkness: Modeling Public-Private Funding Interactions Inside the R&D Black Box [PDF]
This paper is a first step toward closing the analytical gap in the extensive literature on the results of interactions between public and private R&D expenditures, and their joint effects on the economy.
Bronwyn H. Hall, Paul A. David
core +2 more sources
R&D tax credits, innovative activity and the targeting approach
Economics and Business ReviewThe aim of this study is to investigate whether the French R&D tax credit targeted at small and medium-sized enterprises (SMEs) has a positive impact on innovative activity. The French institutional setting provides a unique research framework as the R&D
Gjymshana Erik +2 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The Job Creation Effect of R&D Expenditures [PDF]
In this study we use a unique database covering 25 manufacturing and service sectors for 16 European countries over the period 1996-2005, for a total of 2,295 observations, and apply GMM-SYS panel estimations of a demand-for-labour equation augmented ...
Bogliacino, Francesco, Vivarelli, Marco
core
UK's net-zero carbon emissions target: Investigating the potential role of economic growth, financial development, and R&D expenditures based on historical data (1870-2017). [PDF]
Technol Forecast Soc Change, 2020 Shahbaz M +3 more
europepmc +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Tax competitiveness and business R&D expenditures: do taxes matter for innovation?
Business, Management and Economics EngineeringPurpose – tax policies can be seen as one of the factors potentially affecting firms’ investment decisions and innovation. The paper examines the relationship between tax competitiveness and business Research and Development (R&D) expenditures across EU
Jan Hunady, Eleonora Demeova
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source