Results 251 to 260 of about 640,932 (312)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Addressing Health Inequalities in Greece: A Comprehensive Framework for Socioeconomic Determinants of Health. [PDF]

Healthcare (Basel)
Triantafyllou C, Latsou D, Psiakis V, Pierrakos G, Breda J.   +4 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Health Expenditures Decline After Bariatric Surgery for Patients With Type 2 Diabetes. [PDF]

Diabetes Care
Sloan CE, Zepel L, Smith VA, Arterburn DE, Baecker A, Clark AG, Kawatkar AA, Kane RM, Daigle CR, Coleman KJ, Maciejewski ML.   +10 more
europepmc   +1 more source

Aggregate R&D expenditure and endogenous economic growth

, 2006
Freire Serén, María Jesús, Universitat Autònoma de Barcelona. Unitat de Fonaments de l'Anàlisi Econòmica, Institut d'Anàlisi Econòmica   +2 more
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Impact of timing of treatment for cardiac implantable electronic device infections on healthcare utilization and expenditures. [PDF]

Europace
Pokorney SD, Zepel L, Greiner MA, Lewis RK, Hegland DD, Granger CB, Epstein LM, Carrillo RG, Piccini JP.   +8 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Healthcare Provision Shifts Under DIP Reform: From Conventional Medicine to Traditional Medicine. [PDF]

Inquiry
Pan X, Dai Z, Xiao Y, Ma C, Wang D, Wu J.   +5 more
europepmc   +1 more source

4. Expenditure of firms on R D in different structural markets

Pressacademia, 2016
openaire   +1 more source