Results 131 to 140 of about 657,982 (247)

El papel de los servicios de interés general en la reforma de la legislación española de régimen local

Revista de Estudios de la Administración Local y Autonómica, 2008
Casimiro López García
doaj   +3 more sources

Pathological Response of Locally Recurrent Rectal Cancer to Neoadjuvant Chemoradiotherapy. [PDF]

J Anus Rectum Colon
Yokoyama Y, Ozaki K, Nozawa H, Sasaki K, Murono K, Emoto S, Kaneko K, Matsuzaki H, Abe S, Nagai Y, Shinagawa T, Ishihara S.   +11 more
europepmc   +1 more source

Breves «primeras impresiones» ante un nuevo proceso de reforma del Régimen Local [PDF]

, 2006
Rivero Ysern, José Luis
core   +2 more sources

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Economic distress and discourse : the rise of a corporatist rhetoric in Northern Spain after World War I [PDF]

The paper explores the relationship between language and economy, between text and context, through a case study: the Basque region in northern Spain during World War I and the immediate postwar years.
Juan Carlos Rojo Cagigal
core  

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Protocol for a phase 2, partially blinded, randomized trial assessing the safety and efficacy of sorfequiline or bedaquiline in combination with pretomanid and linezolid in adult participants with newly diagnosed, drug-sensitive, smear-positive pulmonary tuberculosis (NC-009). [PDF]

Trials
Olugbosi M, Beumont M, Lombard L, Nedelman J, Timm J, Black T, Bruning-Barry R, Hickman D, Lombardi A, Betteridge M, Egizi E, Marcopulos L, Henderson J, Seidel S, Foraida S, Benhayoun M, Sun E.   +16 more
europepmc   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

La provincia en el contexto jurídico del Siglo XXI

Revista de Estudios de la Administración Local y Autonómica, 2007
Blanca Soro Mateo
doaj   +3 more sources

LA CRISIS DEL REGIMEN LOCAL INGLES.

Revista de Estudios de la Administración Local y Autonómica, 1956
Manuel Pérez Olea
doaj   +3 more sources