Results 121 to 130 of about 112,087 (240)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Propuesta de creación del Servicio Express para vehículos de mantenimientos limpios y periódicos en el taller "Granados" de automotores y anexos S.A. [PDF]
, 2011 This thesis project analyzes the mechanical service for periodic maintenances in Taller “Granados” of TallerAuto S.A. To do this, processes involved in the service are taken into account giving more emphasis on the maintenance and cleaning processes ...
Hidalgo Bravo, Beatriz Alejandra +1 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
De galán inadaptado a santo: las relaciones jerárquicas del santo con su entorno humano en El serafín humano de Lope de Vega [PDF]
, 2005 À travers les comportements verbaux (et, en particulier le tutoiement ou le vouvoiement), nous étudions dans ce travail les relations hiérarchiques qui structurent l'entourage humain de Francisco dans le premier acte de la comedia hagiographique El ...
Coll Sansalvador, Andreu
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Configuração e interrogação com sistemas federados [PDF]
, 2010 Apesar da existência de produtos comerciais e da investigação na área, a construção de sistemas de informação com diversos componentes distribuídos, heterogéneos e autónomos - conhecidos como sistemas de informação federados - é ainda um desafio.
Cruz, Hugo Miguel Ferreira da
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Experimentació amb un receptor software GPS-Galileo d'alta sensibilitat per a entorns interiors [PDF]
, 2009 Este proyecto se centra en el análisis de señales GPS, utilizando un receptor software desarrollado con Matlab en un proyecto de investigación para la Agencia Espacial Europea (ESA), llevado a cabo por parte del departamento de Telecomunicaciones e ...
López Salcedo, José Antonio +2 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
A prototipagem rápida na modelação de patologias [PDF]
, 2009 A utilização da prototipagem rápida tem, cada vez mais, vindo a revelar-se como uma ferramenta de extremo valor no apoio à actividade médica. Partindo de imagens médicas bidimensionais provenientes de Tomografia Computorizada (TC) ou Ressonância ...
Barbosa, Tiago M. +5 more
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