Results 81 to 90 of about 112,087 (240)
Creating and evaluating replicas of surfaces machined by laser beam
MATEC Web of Conferences, 2017 In industrial practice, we often encounter a problem when it is necessary to measure and subsequently evaluate the surface quality of the part produced by the water jet, laser cutting.
Kubišová Milena +2 more
doaj +1 more source
Una "Adoración de los Reyes Magos" de Artus Wolffort rescatada del anonimato [PDF]
, 2010 La Adoración de los Reyes Magos, pintura anónima en el coleccionismo madrileño, fue catalogada en la galería Sotheby's en el circuito de los discípulos de Rubens por la familiaridad de algunos modelos, pero el lenguaje de su textura y composición está en
Díaz Padrón, Matías
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
La primera réplica en la Propalladia de Torres Naharro [PDF]
, 2001 Se analiza en este artículo la primera réplica en los Introitos e inicios de las Jornadas de algunas de las comedias de Torres Naharro (Soldadesca, Tinellaria, Ymenea, Jacinta, Aquilina y Serafina) publicadas en su Propalladia (1517).
Canet Vallés, José Luis
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Simvastatine resistence test in prostate cells [PDF]
, 2018 [Resumen] El cáncer de próstata es considerado uno de los problemas médicos más importantes a nivel mundial, con una incidencia y prevalencia crecientes en la población masculina mayor de 65 años.
Janeiro Tato, Iria
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Estudio de la series sísmicas ocurridas en 2010 en la costa almeriense [PDF]
, 2011 En este trabajo se presenta un análisis de las series sísmicas registradas durante los meses de julio y noviembre de 2010 en el sector noreste del mar de Alborán, cerca de Almería.
Benito Oterino, Belén +2 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source