Results 81 to 90 of about 2,999,114 (251)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Diagnostic moléculaire du complexe Mycobacterium tuberculosis résistant à l'isoniazide et à la rifampicine au Burkina Faso

The Pan African Medical Journal, 2015
INTRODUCTION: cette étude a eu pour objectifs de diagnostiquer la tuberculose pulmonaire par l'examen microscopique et par la PCR des crachats et de déterminer les bases moléculaires de la résistance à la rifampicine et à l'isoniazide.
Ilboudo Désire, Bisseye Cyrille, Djigma Florencia, Diande Souba, Yonli Albert, Bazie Jean Telesphore Valerie, Compaore Rebecca, Gnoula Charlemagne, Djibril Tamboura, Moret Rémy, Pietra Virginio, Karou Damintoti Simplice, Ouedraogo Martial, Simpore Jacques   +13 more
doaj   +1 more source

Red alert on the plant-parasitic nematodes of banana [PDF]

, 2008
A mutant of 'Grande Naine', the cultivar MAI3 (Mt/sa AAA, Cavendish subgroup) has been selected in the field in Martinique for its good horticultural characteristics (hardiness, bunch conformation, productivity...).
Maton, Clarisse, Quénéhervé, Patrick, Salmon, Frédéric, Soler, Alain, Topart, Patrick   +4 more
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Résistance à la cowdriose de chèvres Créole en Guadeloupe. Bilan en 1988 [PDF]

, 1991
Le taux de résistance à la cowdriose de chèvres Créole en Guadeloupe, varie beaucoup suivant les contacts antérieurs avec la cowdriose. Le taux de résistance à une infection expérimentale varie de 25 p.
Barré, Nicolas, Camus, Emmanuel, Gogue, J.M., Matheron, Gérard   +3 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Preliminary test on modified clays for seawater resistant drilling fluids [PDF]

, 2015
The quality of a drilling fluid declines in salt water conditions. An engineered clay (HYPER clay) was developed for geosynthetic clay liners with enhanced resistance to aggressive conditions.
Bezuijen, Adam, D, Verastegui Flores, den Hamer, Davina, Di Emidio, Gemmina   +3 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Les travailleuses du sexe et la vie économique : marginalisation et résistance

Criminologie, 2010
Adoptant une approche du travail du sexe comme forme de travail dans le domaine des services, cet article explore comment les travailleuses du sexe, malgré leur autodéfinition comme travailleuses et consommatrices, sont maintenues en marge de la vie ...
Colette Parent, Chris Bruckert
doaj   +1 more source