Results 141 to 150 of about 3,502,443 (305)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Latent Profile Analysis of Violent Offenders Based on PCL-R Factor Scores: Criminogenic Needs and Recidivism Risk. [PDF]

Front Psychiatry, 2019
Lehmann RJB, Neumann CS, Hare RD, Biedermann J, Dahle KP, Mokros A.   +5 more
europepmc   +1 more source

A refined r-factor algorithm for TVD schemes on arbitrary unstructured meshes [PDF]

, 2016
A refined r-factor algorithm for implementing TVD schemes on arbitrary unstructured meshes, referred to henceforth as FFISAM (a Face-perpendicular Far-upwind Interpolation Scheme for Arbitrary Meshes), is proposed based on an extensive review of the ...
,, Cheng, L, Jiang, C, Liang, D, Zhang, D   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

El Giro de Lenin o el Factor-R de la Comunicación

Revista Mad, 2012
La identidad puede ser modelada por el enfoque matemático cualitativo de Spencer-Brown, introduciendo la identidad como un tema acordado entre el observador de primer orden y de segundo orden durante una situación comunicativa.
Dirk Baecker
doaj  

The R-factor gap in macromolecular crystallography: an untapped potential for insights on accurate structures. [PDF]

FEBS J, 2014
Holton JM, Classen S, Frankel KA, Tainer JA.   +3 more
europepmc   +1 more source

Meniscal Repair: The R-Factor [PDF]

Clinics in Sports Medicine, 2020
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Validation of an instrument for understanding school absence: the Swedish version of the adapted school refusal assessment scale-revised

BMC Psychology
Background The School Refusal Assessment Scale-Revised (SRAS-R) is a widely used measure to understand school attendance problems. However, previous evaluations have yielded inconsistent findings on the factor structure.
Johan Strömbeck, David Heyne, Laura Ferrer-Wreder, Katarina Alanko   +3 more
doaj   +1 more source