Results 61 to 70 of about 17,031,818 (292)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Factor Analysis For Librarians in R

open access: yesCode4Lib Journal, 2019
This paper offers a primer in the programming language R for library staff members to perform factor analysis. It presents a brief overview of factor analysis and walks users through the process from downloading the software (R Studio) to performing the ...
Michael Carlozzi
doaj  

Identification and Elaboration of Statistical Variables Through Multivariates Techniques in the Study of the Production Grain and Fiber, in Administrative Region of Presidente Prudente-SP

open access: yesSemina: Ciências Exatas e Tecnológicas, 2014
This work deals with the study to obtain statistical variables through multivariate techniques applied to the data of grain and fiber production in the Administrative Region of Presidente Prudente-SP, and is based on the fact that the region be ...
Eduardo Cardoso de Oliveira   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Comparison of two methods of erosive rains determination

open access: yesContributions to Geophysics and Geodesy, 2014
Number of erosive rains, kinetic energy of erosive rains and factor of erosive efficiency of rains according to the USLE methodology were assessed by two methods of erosive rains determination. The first method (VAR1) defined erosive rains by intensity ≥
Hana STŘEDOVÁ   +3 more
doaj   +1 more source

THE MECHANISMS OF TRANSFER OF R FACTORS

open access: yesThe Keio Journal of Medicine, 1967
Kinetic studies of transfer of R and F factors showed that transfer events distribute with a single-peaked homologous pattern in established (normal state) R factor as well as its HFRT systems and F' factor. These results indicate that the differences of transmission frequencies in these states are due to the differ-ences in the number of transmissible
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

R Factors from Proteus morganii [PDF]

open access: yesJournal of General Microbiology, 1973
Summary: Twenty-eight R factors transmissible to Escherichia coli K12 were derived from 178 naturally occurring strains of Proteus morganii and evidence was found of non-transmissible resistance plasmids in some strains. Nine plasmids were assigned to group N; one P. morganii strain carried two N plasmids which were incompatible in reference strains of
R W, Hedges   +3 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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