Results 21 to 30 of about 2,612 (195)

Inhibition of dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 dd-Peptidase [PDF]

Biochemistry, 2013
Inhibitors of bacterial DD-peptidases represent potential antibiotics. In the search for alternatives to β-lactams, we have investigated a series of compounds designed to generate transition state analogue structures upon reaction with DD-peptidases. The compounds contain a combination of a peptidoglycan-mimetic specificity handle and a warhead capable
Dzhekieva, Liudmila, Adediran, S. A., Herman, Raphaël, Kerff, Frédéric, Duez, Colette, Charlier, Paulette, Sauvage, Eric, Pratt, R. F.   +7 more
openaire   +5 more sources

Primary and predicted secondary structure of the Actinomadura R39 extracellular dd-peptidase, a penicillin-binding protein (PBP) related to the Escherichia coli PBP4 [PDF]

Biochemical Journal, 1992
As derived from gene cloning and sequencing, the 489-amino-acid DD-peptidase/penicillin-binding protein (PBP) produced by Actinomadura R39 has a primary structure very similar to that of the Escherichia coli PBP4 [Mottl, Terpstra & Keck (1991) FEMS Microbiol. Lett. 78, 213-220]. Hydrophobic-cluster analysis of the two proteins shows that, providing
Granier, Benoît, Duez, Colette, Englebert, Serge, Dusart, Jean, Dideberg, Otto, Van Beeumen, Jozef, Frère, Jean-Marie, Ghuysen, Jean-Marie, Lepage, Sophie   +8 more
core   +7 more sources

dd -Carboxypeptidase-Transpeptidase and Killing Site of β-Lactam Antibiotics in Streptomyces Strains R39, R61, and K11 [PDF]

Antimicrobial Agents and Chemotherapy, 1973
Additional evidence is given that in Streptomyces strains R39, R61, and K11 the same enzyme performs dd -carboxypeptidase and transpeptidase activities and that this enzyme is the killing site of β-lactam antibiotics. With strain R61, it was found that the exocellular enzyme has a sensitivity
Dusart, Jean, Marquet, Alberto, Ghuysen, Jean-Marie, Frère, Jean-Marie, Moreno, Ramon, Leyh-Bouille, Mélina, Johnson, Kenneth, Lucchi, Chantal, Perkins, Harnold R., Nieto, Manuel   +9 more
openaire   +4 more sources

Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors

Journal of Medicinal Chemistry, 2009
Penicillin binding proteins (PBPs) catalyze steps in the biosynthesis of bacterial cell walls and are the targets for the beta-lactam antibiotics. Non-beta-lactam based antibiotics that target PBPs are of interest because bacteria have evolved resistance to the beta-lactam antibiotics.
Inglis, Steven R., Zervosen, Astrid, Woon, Esther C.Y., Gerards, Thomas, Teller, Nathalie, Fischer S, Delphine, Luxen, André, Schofield, Christopher J.   +7 more
openaire   +5 more sources

Improving Surgical Innovation: A Cross-Sectional Survey of Perceived Facilitators and Barriers. [PDF]

World J Surg
New technologies, processes, or care models that substantially change practice are critical for surgical progress, patient care, and organizational efficiency.
Baker CR, Appelt J, Villafranca AA, Eckert CM, Sexton KW.   +4 more
europepmc   +2 more sources

Investigating Potential Adverse Drug Reactions of Lisdexamfetamine Using Sequence Symmetry Analysis [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT The prevalence of ADHD is increasing rapidly, and lisdexamfetamine is increasingly popular, but few studies investigate its safety. We performed a sequence symmetry analysis (SSA) using Danish register data to identify potential ADRs associated with lisdexamfetamine in 2013–2023.
Jensen T, Thysen S, Jimenez‐Solem E, Jørgensen A, Jensen C, Råket H, Osler M, Nielsen M, Lund L.   +8 more
europepmc   +2 more sources

Haemodialysis Nurses' Self-Reported Cultural Competence and Responsiveness: A Cross-Sectional Survey. [PDF]

J Ren Care
ABSTRACT Background People receiving in‐centre haemodialysis have distinct cultural care needs and preferences, and nurses are expected to respond to these. However, haemodialysis nurses' cultural competence and responsiveness are unknown. Objectives To examine nurses' cultural competence and responsiveness when caring for people with diverse cultural ...
Aryal S, Wynne R, Hyun A, Bennett PN, Bloomer MJ.   +4 more
europepmc   +2 more sources

Lessons from the US and German Reit Markets for Drafting a Polish Reit Act

Real Estate Management and Valuation, 2022
Investors are increasingly allocating capital into the real estate market through indirect investment vehicles such as REITs. There are currently no classic REITs in Poland, but given the experience of other countries and the expectations of Polish ...
Kowalke Krzysztof, Funk Bernhard
doaj   +1 more source

Determinants of Variance in Cost Method of Valuation in Uyo, Nigeria

Real Estate Management and Valuation, 2021
Variance in the cost method of valuation as caused by certain variables is objectionable in the profession of estate surveying and valuation at both local and international best practices.
Anih Paul C., Usenemana Sunday
doaj   +1 more source

Citrullination of HP1γ chromodomain affects association with chromatin

Epigenetics & Chromatin, 2019
Background Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principal reader of the repressive histone
Meike Wiese, Andrew J. Bannister, Srinjan Basu, Wayne Boucher, Kai Wohlfahrt, Maria A. Christophorou, Michael L. Nielsen, David Klenerman, Ernest D. Laue, Tony Kouzarides   +9 more
doaj   +1 more source