Results 121 to 130 of about 12,365,970 (288)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The cg Package for Comparison of Groups

Journal of Statistical Software, 2013
In research of medicines, the comparison of treatments, test articles, conditions, administrations, etc., is very common. Studies are completed, and the data are then most often analyzed with a default mixture of equal variance t tests, analysis of ...
Bill Pikounis, John Oleynick
doaj  

Factor Analysis using R

, 2013
R (R Development Core Team, 2011) is a very powerful tool to analyze data, that is gaining in popularity due to its costs (its free) and flexibility (its open-source). This article gives a general introduction to using R (i.e., loading the program, using functions, importing data). Then, using data from Canivez, Konold, Collins, and Wilson (2009), this
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

El factor de modificación de respuesta, R, para edificios de período corto

Revista de I + D Tecnológico, 2002
La aplicación del Factor de Modificación de Respuesta, R, en la estimación del cortante sísmico basal (ATC-3-06), reconoce la habilidad de una estructura para disipar energía en el rango inelástico.
Óscar Ramírez
doaj  

A Latent Profile Analysis of Violent Offenders Based on PCL-R Factor Scores: Criminogenic Needs and Recidivism Risk. [PDF]

Front Psychiatry, 2019
Lehmann RJB, Neumann CS, Hare RD, Biedermann J, Dahle KP, Mokros A.   +5 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Factor Analysis for Multiple Testing (FAMT): An R Package for Large-Scale Signi

Journal of Statistical Software, 2011
The R package FAMT (factor analysis for multiple testing) provides a powerful method for large-scale significance testing under dependence. It is especially designed to select differentially expressed genes in microarray data when the correlation ...
David Causeur, Chloe Friguet, Magalie Houee-Bigot, Maela Kloareg   +3 more
doaj  

The R-factor gap in macromolecular crystallography: an untapped potential for insights on accurate structures. [PDF]

FEBS J, 2014
Holton JM, Classen S, Frankel KA, Tainer JA.   +3 more
europepmc   +1 more source