Results 91 to 100 of about 8,158,678 (300)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

WhatIF: R Software for Evaluating Counterfactuals [PDF]

WhatIf is an R package that implements the methods for evaluating counterfactuals introduced in King and Zeng (2006a) and King and Zeng (2006b). It offers easy-to-use techniques for assessing a counterfactual's model dependence without having to conduct ...
Gary King, Heather Stoll, Langche Zeng
core   +1 more source

GeantV: Results from the prototype of concurrent vector particle transport simulation in HEP

, 2020
Full detector simulation was among the largest CPU consumer in all CERN experiment software stacks for the first two runs of the Large Hadron Collider (LHC).
Amadio, G., Ananya, A., Apostolakis, J., Bandieramonte, M., Banerjee, S., Bhattacharyya, A., Bianchini, C., Bitzes, G., Canal, P., Carminati, F., Chaparro-Amaro, O., Cosmo, G., Drogan, V., Duhem, L., Elvira, D., Fuentes, J., Gheata, A., Gheata, M., Goulas, I., Gravey, M., Hariri, F., Jun, S. Y., Konstantinov, D., Kumawat, H., Licht, J. C. De Fine, Lima, J. G., Maldonado-Romo, A., Martínez-Castro, J., Mato, P., Nikitina, T., Novaes, S., Novak, M., Pedro, K., Pokorski, W., Ribon, A., Schmitz, R., Seghal, R., Shadura, O., Tcherniaev, E., Vallecorsa, S., Wenzel, S., Zhang, Y.   +41 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Homalg: A meta-package for homological algebra

, 2007
The central notion of this work is that of a functor between categories of finitely presented modules over so-called computable rings, i.e. rings R where one can algorithmically solve inhomogeneous linear equations with coefficients in R.
Björk J.-E., Cartan H., DANIEL ROBERTZ, Decker W., Kreuzer M., MOHAMED BARAKAT, Roos J.-E., Rotman J. J.   +7 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Analysis of Gene Expression, Signaling Pathways, and Interaction Networks of Some Effective Genes in Patients with Asthma in Microarray Studies Using R Software

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Asthma is a chronic inflammatory disorder of the airways caused by a combination of complex environmental and genetic interactions.
Saeed Pirmoradi
doaj  

Development of an application for accessing and analyzing RDPLF data

Bulletin de la Dialyse à Domicile, 2020
The collection of information in the database of a medical registry finds its first interest in the possibility for a doctor and a care team to analyze their results and to compare themselves with other teams for the purpose of sharing experience and ...
Benoit Thieurmel, Martin Masson
doaj   +1 more source