CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Coverage of fluoride data in water supply systems using the R software. [PDF]
Rev Saude Publica, 2022 Paulino CM +3 more
europepmc +1 more source
Monitor-Based Instant Software Refactoring
, 2013 Software refactoring is an effective method for improvement of software quality while software external behavior remains unchanged. To facilitate software refactoring, a number of tools have been proposed for code smell detection and/or for automatic or ...
Guo, Xue, Liu, Hui, Shao, Weizhong
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Protocol to analyze dysregulation of the eIF4F complex in human cancers using R software and large public datasets. [PDF]
STAR Protoc, 2022 Wu S, Wagner G.
europepmc +1 more source
Review of HSMM R and Python softwares [PDF]
This chapter provides a comprehensive review of the various software and packages available for hidden semi-Markov models (HSMMs) or with a particular focus on those related to the themes of this book: multichain models, coupled chains and the incorporation of covariates.
Bérard, Caroline +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Analysis of Statistically Predicted Rate Constants for Pyrolysis of High-Density Plastic Using R Software. [PDF]
Materials (Basel), 2022 Nabi RAU +13 more
europepmc +1 more source
A Software Engineering Experiments to value MDE in testing. Learning Lessons [PDF]
, 2016 Controlled experiments are commonly used to evaluate Software Engineering methods, processes and tools. Validating results of Software Engineering re search in industrial settings is a direct way to obtain feedback about its value.
García García, Julián Alberto +5 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source