Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Protocol to analyze dysregulation of the eIF4F complex in human cancers using R software and large public datasets. [PDF]
STAR Protoc, 2022 Wu S, Wagner G.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Analysis of Statistically Predicted Rate Constants for Pyrolysis of High-Density Plastic Using R Software. [PDF]
Materials (Basel), 2022 Nabi RAU +13 more
europepmc +1 more source
An Introduction to the 'Special Volume Spectroscopy and Chemometrics in R' [PDF]
This special volume collates ten issues under the rubric "Spectroscopy and Chemometrics in R". In so doing, it provides an overview of the breadth, depth and state of the art of R-based software projects for spectroscopy and chemometrics applications ...
Ivo H. M. van Stokkum +1 more
core +1 more source
Towards a Soil Information System with quantified accuracy : a prototype for mapping continuous soil properties [PDF]
, 2010 This report describes the potential and functionality of software for spatial analysis, prediction and stochastic simulation of continuous soil properties using data from the Dutch Soil Information System (BIS).
Brus, D.J. +5 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Easyreporting simplifies the implementation of Reproducible Research layers in R software. [PDF]
PLoS One, 2021 Righelli D, Angelini C.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Strategic Patenting and Software Innovation [PDF]
Strategic patenting is widely believed to raise the costs of innovating,especially in industries characterised by cumulative innovation. This paperstudies the effects of strategic patenting on R&D, patenting and marketvalue in the computer software ...
Mark Schankerman, Michael Noel
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