Results 121 to 130 of about 8,158,678 (300)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Machine learning-aided first-principles calculations of redox potentials

open access: yesnpj Computational Materials
We present a method combining first-principles calculations and machine learning to predict the redox potentials of half-cell reactions on the absolute scale.
Ryosuke Jinnouchi   +2 more
doaj   +1 more source

Cost-Efficient and Quality of Experience-Aware Provisioning of Virtual Machines for Multiplayer Cloud Gaming in Geographically Distributed Data Centers

open access: yesIEEE Access, 2019
Prompted by the remarkable progress in both cloud computing and GPU virtualization, cloud gaming has become increasingly more popular in the gaming industry.
Yongqiang Gao, Lin Wang, Jiantao Zhou
doaj   +1 more source

Econometrics in R: Past, Present, and Future [PDF]

open access: yes
Recently, computational methods and software have been receiving more attention in the econometrics literature, emphasizing that they are integral components of modern econometric research.
Achim Zeileis, Roger Koenker
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Open source software and R&D competition in software industries

open access: yesProcedia Engineering, 2011
AbstractBy modifying Cournot model, this paper compares the R&D competition in a duopoly industry when two proprietary software (PS) producers compete and when a proprietary software producer competes with open source software (OSS) producer. This paper assumes proprietary software producer pursues profit maximization and open source software is free ...
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

HOW TO PERFORM A META-ANALYSIS: A PRACTICAL STEP-BY-STEP GUIDE USING R SOFTWARE AND RSTUDIO. [PDF]

open access: yesActa Ortop Bras, 2022
Ariel de Lima D   +5 more
europepmc   +1 more source

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