Results 121 to 130 of about 21,114 (301)
The effect of RAA on mRNA degradation in THP-1 human leukemic monocytes
, 2005 Dysregulation of mRNA levels is a genetic hallmark of cancer. The Shaw-Kamen (SK) box, an AU-rich element (ARE ) found in the 3'UTR, is an mRNA stability determinant in many cytokines, growth factors, transcription factors, and proto-oncogene mRNAs.
Mak, Isabella Wing Yan
core +1 more source
Precision Medical Sciences, EarlyView.Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley +1 more source
Stereotactic Prostate Cancer Ablative Re‐Irradiation: A Systematic Review and Meta‐Analysis (SPARE)
The Prostate, EarlyView.ABSTRACT Background Stereotactic ablative radiotherapy (SABR) is emerging as an alternative treatment for patients with locally recurrent prostate cancer after previous radiation. This approach allows for precise target coverage while limiting toxicity to surrounding organs.
Andre G. Gouveia +12 more
wiley +1 more source
Pest Management Science, EarlyView.This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti +3 more
wiley +1 more source
, 2019 During the June 2015 European Workshop on Efficiency and Productivity Analysis in Helsinki, we sat together and tried to map a broad view of performance analysis. The prevailing approach is frontier analysis. The production frontier of a “decision making
Greene, William, ten Raa, M.H.
core
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said +10 more
wiley +1 more source
Phytotherapy Research, EarlyView.Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng +6 more
wiley +1 more source
Phytotherapy Research, EarlyView.Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli +6 more
wiley +1 more source
Sustainable Development, EarlyView.ABSTRACT This research explores to what extent the ideas and notions of sustainable project management (SPM) are reflected in the project management methodologies of three selected international development agencies. A conceptual framework is developed, and a deductive content analysis is performed.
Jan Christoph Albrecht +4 more
wiley +1 more source
RAA v1.1 — Figures and Supplementary Materials
Repository for diagrams, figures, and supplementary materials associated with RAA/RDL v1 ...
Nicolas Holm
core