Results 11 to 20 of about 649 (103)

Rab4b Promotes Cytolethal Distending Toxin from Glaesserella parasuis-Induced Cytotoxicity in PK-15 Cells [PDF]

Toxins
Glaesserella parasuis cytolethal distending toxin (GpCDT) can induce cell cycle arrest and apoptosis. Our laboratory’s previous work demonstrated that GTPase 4b (Rab4b) is a key host protein implicated in GpCDT-induced cytotoxicity.
Yiwen Zhang, Zhen Yang, Ke Dai, Bangdi Hu, Shiyu Xu, Yu Wang, Li Lei, Senyan Du, Qin Zhao, Xiaobo Huang, Rui Wu, Qigui Yan, Yiping Wang, Sanjie Cao, Yiping Wen   +14 more
doaj   +5 more sources

Host Factor Rab4b Promotes Japanese Encephalitis Virus Replication [PDF]

Microorganisms
Although the Japanese encephalitis virus (JEV) infects various cell types, its receptor molecules are still not clearly understood. In our laboratory’s prior research, Rab4b was identified as a potential host factor that facilitates JEV infection in PK15
Qin Zhao, Chang Miao, Yi-Ting Chen, Long-Yue Zhu, Ya-Ting Zhang, Sai-Qi Luo, Yu-Luo Wang, Zhu-Ming Zhu, Xinfeng Han, Yiping Wen, Rui Wu, Senyan Du, Qi-Gui Yan, Xiaobo Huang, Shan Zhao, Yi-Fei Lang, Yiping Wang, Yi Zheng, Fei Zhao, San-Jie Cao   +19 more
doaj   +5 more sources

Host Factor Rab4b Promotes the Replication of Influenza A Virus [PDF]

Biosafety and Health
Rab proteins are involved in all facets of the vesicular transport process and play significant roles in different steps of the viral life cycle. Rab4b is a pivotal player in the endocytic recycling of proteins, whereas its roles in viral replication are
Saisai Guo, Jianyuan Zhao
exaly   +6 more sources

Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

Cell Reports, 2018
Summary: Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the ...
Arnaud Jacquel, Mireille Cormont, Stoyan Ivanov   +2 more
exaly   +7 more sources

Rab4b Is a Small GTPase Involved in the Control of the Glucose Transporter GLUT4 Localization in Adipocyte [PDF]

PLoS ONE, 2009
Endosomal small GTPases of the Rab family, among them Rab4a, play an essential role in the control of the glucose transporter GLUT4 trafficking, which is essential for insulin-mediated glucose uptake.
Mireille Cormont, Philippe Gual, Jean Gugenheim   +2 more
exaly   +8 more sources

Host Factor Rab4b Mediates Internalization and Intoxication of 3D4/21 Cells by the Active Subunit of the Glaesserella parasuis Cytolethal Distending Toxin via Influencing EEA1 Expression [PDF]

Frontiers in Microbiology
BackgroundThe cytolethal distending toxin (CDT), a significant exotoxin, is closely linked to the pathogenicity of Glaesserella parasuis (GPS), but its pathogenic not yet fully elucidated.
Qigui Yan, Qin Zhao, Yiping Wen
exaly   +6 more sources

Golgi-Associated Retrograde Protein (GARP) Complex-Dependent Endosomes to Trans Golgi Network Retrograde Trafficking Is Controlled by Rab4b [PDF]

Cellular and Molecular Biology Letters
Background The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Mireille Cormont, Jean-François Tanti, Sandra Lacas-Gervais   +2 more
exaly   +6 more sources

Rab4b Controls Hepatic Glucose Production During Fasting Through Glycophagy [PDF]

Nature Communications
Hepatic glucose production, essential for maintaining glycemia, is often altered in metabolic-associated fatty liver and glycogen storage diseases. Therefore, understanding the mechanisms that regulate the glucose production by hepatocyte is pivotal ...
Mireille Cormont, Stoyan Ivanov, Alexandre Gallerand   +2 more
exaly   +4 more sources

Chromosome 19q13 Disruption Alters Expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and Contributes to FAP-Like Phenotype in APC Mutation-Negative Familial Colorectal Cancer Patients [PDF]

PLoS ONE, 2017
Familial adenomatous polyposis (FAP) is an autosomal-dominantly inherited form of colorectal cancer (CRC) caused by mutation in the adenomatous polyposis coli (APC) gene. Our ability to exhaustively screen for APC mutations identify microsatellite-stable
Peh Yean Cheah, Min Hoe Chew, Michelle Lo   +2 more
exaly   +6 more sources

Preliminary Exploration of the Potential Biological Functions and Prognosis Values of RAB4B in Pan-Cancer Combing With Experimental Validation in BLCA [PDF]

Translational Cancer Research
Ras-related protein Rab-4B (RAB4B), a small GTPase in the RAS superfamily, is involved in glucose homeostasis, synaptic homeostasis, adaptive immunity, and other processes. RAB4B has also been implicated in tumorigenesis, and its dysregulation has been linked to cancer in multiple organs.
Kezhen Li, Shengsheng Liang
exaly   +4 more sources