Results 31 to 40 of about 649 (103)

Rab family of small GTPases: an updated view on their regulation and functions

The FEBS Journal, Volume 288, Issue 1, Page 36-55, January 2021., 2021
The Rab family of small GTPases regulates intracellular membrane trafficking by localizing on specific organelles (or vesicles) and recruiting various effector proteins to facilitate each step of membrane trafficking. In this review article, we provide the most up‐to‐date and comprehensive lists of guanine nucleotide exchange factors, GTPase‐activating
Yuta Homma, Shu Hiragi, Mitsunori Fukuda
wiley   +1 more source

Refining susceptibility loci of chronic obstructive pulmonary disease with lung eqtls. [PDF]

PLoS ONE, 2013
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of mortality worldwide. Recent genome-wide association studies (GWAS) have identified robust susceptibility loci associated with COPD.
Maxime Lamontagne, Christian Couture, Dirkje S Postma, Wim Timens, Don D Sin, Peter D Paré, James C Hogg, David Nickle, Michel Laviolette, Yohan Bossé   +9 more
doaj   +1 more source

Evaluation of Important Molecular Pathways and Candidate Diagnostic Biomarkers of Noninvasive to Invasive Stages in Gastric Cancer by In Silico Analysis

Journal of Oncology, Volume 2021, Issue 1, 2021., 2021
Gastric cancer affects millions of people each year; it is the fifth deadliest cancer globally. Due to failure to perform routine tests such as endoscopy, it is usually diagnosed in the invasive stages. Therefore, finding diagnostic biomarkers in blood can help to speed up the initial diagnosis of cancer. This study aimed to find appropriate diagnostic
Sara Tutunchi, Saeedeh Akhavan, Ahmad Bereimipour, Sayyed Mohammad Hossein Ghaderian, Cristina Magi-Galluzzi   +4 more
wiley   +1 more source

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype. [PDF]

PLoS ONE, 2016
Non-muscle invasive (superficial) bladder cancer is a low-grade malignancy with good prognosis, while muscle invasive (invasive) bladder cancer is a high-grade malignancy with poor prognosis.
Kazuhiro Kanemoto, Katsuhiro Fukuta, Noriyasu Kawai, Keiichi Tozawa, Masako Ochiai, Koji Okamoto, Sumiko Ohnami, Hiromi Sakamoto, Teruhiko Yoshida, Yae Kanai, Masaru Katoh, Takahiro Yasui, Kenjiro Kohri, Tadao Kakizoe, Hitoshi Nakagama   +14 more
doaj   +1 more source

Association of Functional Gene Variants in DYSF-ZNF638, MTSS1 and Ferroptosis-Related Genes with Multiple Sclerosis Severity and Target Gene Expression. [PDF]

Int J Mol Sci
Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease with yet-unresolved mechanisms of progression. To address MS severity and neurological deficits, we analyzed seven potentially functional genetic variants and their haplotypes ...
Djuric T, Djordjevic A, Kuveljic J, Stefanovic M, Dincic E, Kolakovic A, Zivkovic M.   +6 more
europepmc   +2 more sources

Components of the endocytic and recycling trafficking pathways interfere with the integrity of the Legionella‐containing vacuole

Cellular Microbiology, Volume 22, Issue 4, April 2020., 2020
Abstract Legionella pneumophila requires the Dot/Icm translocation system to replicate in a vacuolar compartment within host cells. Strains lacking the translocated substrate SdhA form a permeable vacuole during residence in the host cell, exposing bacteria to the host cytoplasm.
Ila S. Anand, Wonyoung Choi, Ralph R. Isberg   +2 more
wiley   +1 more source

Identification of Latent Oncogenes with a Network Embedding Method and Random Forest

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Oncogene is a special type of genes, which can promote the tumor initiation. Good study on oncogenes is helpful for understanding the cause of cancers. Experimental techniques in early time are quite popular in detecting oncogenes. However, their defects become more and more evident in recent years, such as high cost and long time.
Ran Zhao, Bin Hu, Lei Chen, Bo Zhou, Shijia Zhu   +4 more
wiley   +1 more source

Control of mitochondrial functions by endosomal GTPase Rab4bdependent mechanisms

International audienceTo address these objectives, we work on primary CD4+ T cells specifically invalidated for Rab4b using a T cell-specific CRE-Lox system. We studied the mitochondrial activity and mass of CD4+ T cells using fluorescent-specific probes
Cormont, Mireille, Daunas, Lucien, Dolfi, Bastien, Tanti, Jean-François, Mazure, Nathalie, Verbavatz, Jean-Marc, Chafik, Abderrahman, Gilleron, Jérôme   +7 more
core   +7 more sources

Metabolic regulation through the endosomal system

Traffic, Volume 20, Issue 8, Page 552-570, August 2019., 2019
This review explores how the endosomal system regulates glucose and lipid metabolism in vivo in mice and humans. It demonstrates the pivotal functions of endocytic trafficking in sensing extracellular metabolic cues and integrating this information to adapt to the alterations in metabolic homeostasis. Overall, this work highlights exciting new roles of
Jerome Gilleron, Jantje M. Gerdes, Anja Zeigerer   +2 more
wiley   +1 more source

Rab Proteins as Potential Therapeutic Targets Applied to Crustacean Aquaculture: Rab7 Case Analysis

Reviews in Aquaculture, Volume 17, Issue 1, January 2025.
ABSTRACT Rab proteins constitute an important subfamily of molecular effectors whose function is related to the modulation of several important cellular and metabolic processes, including controlling intracellular endocytic vesicle trafficking, phagosome formation, endosome maturation, and innate immunity. In crustaceans, the study and characterization
Carlos Fajardo, Marcos De Donato, Patai Charoonnart, Vanvimon Saksmerprome, Harry O. Jackson, Juan Miguel Mancera, Benjamin Costas   +6 more
wiley   +1 more source