Results 21 to 30 of about 649 (103)

The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing [PDF]

Frontiers in Cell and Developmental Biology, 2022
The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated human genes, the family has a broad expression throughout cells of the body. Members of the family have multiple exons that require splicing.
Akansha S. Das, Akansha S. Das, Emily C. Sherry, Emily C. Sherry, Robert M. Vaughan, Marian L. Henderson, Marian L. Henderson, Jacob Zieba, Jacob Zieba, Katie L. Uhl, Olivia Koehn, Caleb P. Bupp, Caleb P. Bupp, Surender Rajasekaran, Surender Rajasekaran, Surender Rajasekaran, Xiaopeng Li, Surya B. Chhetri, Sahar Nissim, Sahar Nissim, Sahar Nissim, Carol L. Williams, Jeremy W. Prokop, Jeremy W. Prokop, Jeremy W. Prokop   +24 more
doaj   +2 more sources

Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes [PDF]

Nucleic Acids Research, 2006
The small GTPase RAB4 regulates endocytic recycling, a process that contributes to Major Histocompatibility Complex (MHC)-mediated antigen presentation by specialized antigen presenting cells (APC) of the immune system. The gene encoding the RAB4B isoform of RAB4 was singled out by two complementary genome-wide screens.
Krawczyk, Michal, Leimgruber, Elisa, Seguin-Estevez, Queralt, Dunand-Sauthier, Isabelle, Barras, Emmanuele, Reith, Walter   +5 more
openaire   +4 more sources

Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen.

MBio, 2018
As obligate intracellular parasites, viruses are completely dependent on host factors for replication. Assembly and egress of complex virus particles, such as human cytomegalovirus (HCMV), are likely to require many host factors. Despite this, relatively
Dominique McCormick, Yao-Tang Lin, Finn Grey   +2 more
exaly   +3 more sources

Additional file 1 of Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b

Additional file 1: Figure S1. (related to Figure 1). A Index of co-localization between Rab4b and organelle markers. Colocalization between organelle markers and similar level of overexpressed GFP-Rab4b. B Analysis of the co-localization between EEA1 and GFP-Rab4b wt or inactive.
Gilleron, Jérôme, Chafik, Abderrahman, Lacas-Gervais, Sandra, Tanti, Jean-François, Cormont, Mireille   +4 more
openaire   +2 more sources

T cell Rab4b small GTPase implication in obesity-related metabolic complications

, 2018
Lors de l’obésité, les défauts d’expansion du tissu adipeux blanc sont à l’origine des désordres métaboliques. Lorsque les adipocytes atteignent leurs capacités maximales de stockage de triglycérides, des dépôts ectopiques de lipides apparaissent dans le foie et le muscle conduisant à la résistance à l’insuline.
Bouget, Gwenaëlle
openaire   +2 more sources

Effect of PRDX6 gene polymorphism on susceptibility to chronic obstructive pulmonary disease in the Chinese Han population

The Clinical Respiratory Journal, Volume 17, Issue 7, Page 638-646, July 2023., 2023
Table 1. Clinical characteristics of patients with COPD and healthy controls. Abstract Background To explore the relationship of peroxiredoxin6 (PRDX6) tag‐single nucleotide polymorphisms (SNPs) with susceptibility to chronic obstructive pulmonary disease (COPD) in the Chinese Han population.
Mingmei Xiong, Meihua Guo, Dongjian Huang, Jing Li, Yan Zhou   +4 more
wiley   +1 more source

The unconventional way out—Egress of HCMV through multiviral bodies

Molecular Microbiology, Volume 117, Issue 6, Page 1317-1323, June 2022., 2022
Human cytomegalovirus (HCMV) acquires its envelope by budding into cellular membranes. We recently showed that HCMV forms multiviral bodies as a so far undescribed functional egress pathway resulting in the bulk release of large numbers of particles at once.
Linda Wedemann, Felix J. Flomm, Jens B. Bosse   +2 more
wiley   +1 more source

N6‐Methyladenosine Modification Profile in Bovine Mammary Epithelial Cells Treated with Heat‐Inactivated Staphylococcus aureus

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
The symptoms of mastitis caused by Staphylococcus aureus (S. aureus) in dairy cows are not obvious and difficult to identify, resulting in major economic losses. N6‐Methyladenosine (m6A) modification has been reported to be closely associated with the occurrence of many diseases.
Ting Li, Yifan Zhu, Changjie Lin, Jie Chen, Yiya Yin, Xin Tang, Yingyu Chen, Aizhen Guo, Changmin Hu, Zhihao Jia   +9 more
wiley   +1 more source

Genetic Variants Associated with Chronic Obstructive Pulmonary Disease Risk: Cumulative Epidemiological Evidence from Meta‐Analyses and Genome‐Wide Association Studies

Canadian Respiratory Journal, Volume 2022, Issue 1, 2022., 2022
Background. Last two decades, many association studies on genetic variants and chronic obstructive pulmonary disease (COPD) risk have been published. But results from different studies are inconsistent. Therefore, we performed this article to systematically evaluate results from previous meta‐analyses and genome‐wide association studies (GWASs ...
Caiyang Liu, Ran Ran, Xiaoliang Li, Gaohua Liu, Xiaoyang Xie, Ji Li, Sami Deniz   +6 more
wiley   +1 more source

Astrocytic‐neuronal crosstalk gets jammed: Alternative perspectives on the onset of neuropsychiatric disorders

European Journal of Neuroscience, Volume 54, Issue 5, Page 5717-5729, September 2021., 2021
A balanced astrocyte‐neuronal bidirectional communication is essential for the proper development of neuronal synaptic networks. Both astrocyte‐specific released factors and membrane‐bound proteins play key roles in the physiological and pathological formation and function(s) of synaptic connections. Astrocyte‐mediated phagocytosis of neuronal synapses
Celia Roman, Luisa Egert, Barbara Di Benedetto   +2 more
wiley   +1 more source