Results 1 to 10 of about 24,778 (199)
LRRK2 interactions with microtubules are independent of LRRK2-mediated Rab phosphorylation [PDF]
EMBO ReportsDeregulated microtubules are common defects associated with neurodegenerative diseases. Recent cryo-electron microscopy studies in cell lines overexpressing Parkinson’s disease-associated LRRK2 suggest microtubule surfaces may regulate kinase activity by
Tuyana Malankhanova +7 more
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The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes [PDF]
Nature CommunicationsSmall GTP-binding proteins of the Rab, Arf, and Arf-like family mediate the recruitment of their effectors to subcellular membrane-bound compartments, which in turn mediate vesicle budding, motility, and tethering.
Sankalita Paul +12 more
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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
iScience, 2022 Summary: Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1.
Elena Fdez +10 more
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Rab GTPases, tethers, and SNAREs work together to regulate Arabidopsis cell plate formation
Frontiers in Plant Science, 2023 Cell plates are transient structures formed by the fusion of vesicles at the center of the dividing plane; furthermore, these are precursors to new cell walls and are essential for cytokinesis.
Yumei Shi +3 more
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Affinity-based proteomics reveals novel binding partners for Rab46 in endothelial cells
Scientific Reports, 2021 Rab46 is a novel Ca2+-sensing Rab GTPase shown to have important functions in endothelial and immune cells. The presence of functional Ca2+-binding, coiled-coil and Rab domains suggest that Rab46 will be important for coupling rapid responses to ...
Lucia Pedicini +4 more
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European Journal of Entomology, 2023 Rab, a low molecular weight GTP-binding protein, regulates the transmission of intracellular proteins. Insect neuropeptides that are directly involved in growth, development, reproduction, homeostasis, courtship, feeding, circadian rhythm and many other ...
Asuka MATSUI +6 more
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Relationship between Rab and insulin-like proteins in the nervous system of Bombyx mori
European Journal of Entomology, 2021 Rab proteins are small GTP-binding proteins and are the largest family in the Ras GTPase superfamily and mediate vesicular transport in cells. Diverse insulin-like peptides, such as bombyxin, are synthesized in the brain and secreted into the haemolymph ...
Tomohide UNO +7 more
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Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2 [PDF]
, 2020 Rab8a is associated with the dynamic regulation of membrane protrusions in polarized cells. Rab8a is one of several Rab GTPases that are substrates of leucine-rich repeat kinase 2 (LRRK2), a serine/threonine kinase that is linked to Parkinson's disease ...
Alessi, Dario R. +5 more
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bMERB domains are bivalent Rab8 family effectors evolved by gene duplication
eLife, 2016 In their active GTP-bound form, Rab proteins interact with proteins termed effector molecules. In this study, we have thoroughly characterized a Rab effector domain that is present in proteins of the Mical and EHBP families, both known to act in ...
Amrita Rai +8 more
doaj +1 more source
Progress in Fishery Sciences, 2023 The Ras-related proteins in brain (Rab) subfamily is the largest group of small molecule guanine nucleotide-binding regulatory proteins (GTP-binding proteins).
Xinlin SONG +5 more
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