Results 1 to 10 of about 45,175 (206)

rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.

Journal of Biological Chemistry, 1992
p21ras and several other ras-related GTP-binding proteins are modified post-translationally by addition of 15-carbon farnesyl or 20-carbon geranylgeranyl isoprenoids to cysteines within a conserved carboxyl-terminal sequence motif, Caa(M/S/L), where a is an aliphatic amino acid.
B. Therese Kinsella, William A. Maltese
semanticscholar   +4 more sources

Characterization of lysosomal membrane proteins of Dictyostelium discoideum. A complex population of acidic integral membrane glycoproteins, Rab GTP-binding proteins and vacuolar ATPase subunits.

Journal of Biological Chemistry, 1994
Highly purified lysosomes, prepared by magnetic fractionation of homogenates from Dictyostelium discoideum cells fed colloidal iron, were lysed under hypoosmotic conditions, and the membrane-associated proteins were subjected to gel electrophoresis. Thirteen major membrane polypeptides, ranging in molecular weight from 25,000 to 100,000 were identified.
Lesly A. Temesvari, Juan Rodriguez‐Paris, John Bush, Theodore L. Steck, James A. Cardelli   +4 more
semanticscholar   +4 more sources

Removal of Rab GTP-binding proteins from Golgi membranes by GDP dissociation inhibitor inhibits inter-cisternal transport in the Golgi stacks.

Journal of Biological Chemistry, 1994
Rab proteins are a family of Ras-like GTPases involved in intracellular membrane traffic. Rab GDI, a cytosolic protein which inhibits the dissociation of GDP from various Rab proteins, is required to maintain a pool of Rab proteins in the cytosol.
Zvulun Elazar, Thomas U. Mayer, James E. Rothman   +2 more
semanticscholar   +4 more sources

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

Journal of Biological Chemistry, 1989
Seven cDNA clones corresponding to the rab1, rab2, rab3A, rab3B, rab4, rab5, and rab6 genes were isolated from a human pheochromocytoma cDNA library. They encode 23-25 kDa polypeptides which share approximately 30-50% homology and belong to the ras superfamily.
Ahmed Zahraoui, Nicolas Touchot, Pierre Teilhard de Chardin, A Tavitian   +3 more
semanticscholar   +4 more sources

Small GTP binding proteins: Rab GTPases from the brain of Bombyx mori [PDF]

Archives of Insect Biochemistry and Physiology, 2003
AbstractFrom a mRNA of the brain of Bombyx mori, we isolated 8 cDNA clones (BRabs), each of which encodes a different member of Rab‐protein family. Four of them have more than 80% amino acid identity to the corresponding members of Drosophila Rab proteins. The other 4 proteins show low sequence similarity to any of the known Rab proteins.
Tomohide Uno, Susumu Hiragaki
semanticscholar   +4 more sources

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

Journal of Biological Chemistry, 1992
Rab proteins are membrane-bound prenylated GTP-binding proteins required for the targeted movement of membrane vesicles from one organelle to another. In the current paper we have characterized and purified an enzyme that attaches geranylgeranyl residues to Rab proteins that bear the COOH-terminal sequence Cys-X-Cys (such as Rab3A) and Cys-Cys (such as
Miguel C. Seabra, Joseph L. Goldstein, Thomas C. Südhof, Matthew S. Brown   +3 more
semanticscholar   +4 more sources

The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes [PDF]

Nature Communications
Small GTP-binding proteins of the Rab, Arf, and Arf-like family mediate the recruitment of their effectors to subcellular membrane-bound compartments, which in turn mediate vesicle budding, motility, and tethering.
Sankalita Paul, Rajat Pant, Poonam Sharma, Kshitiz Walia, Suhasi Gupta, Adhil Aseem, Kamlesh Kumari Bajwa, Ruben George, Yudish Varma, Tripta Bhatia, Rajesh Ramachandran, Amit Tuli, Mahak Sharma   +12 more
doaj   +2 more sources

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

iScience, 2022
Summary: Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1.
Elena Fdez, Jesús Madero-Pérez, Antonio J. Lara Ordóñez, Yahaira Naaldijk, Rachel Fasiczka, Ana Aiastui, Javier Ruiz-Martínez, Adolfo López de Munain, Sally A. Cowley, Richard Wade-Martins, Sabine Hilfiker   +10 more
doaj   +1 more source

Rab GTPases, tethers, and SNAREs work together to regulate Arabidopsis cell plate formation

Frontiers in Plant Science, 2023
Cell plates are transient structures formed by the fusion of vesicles at the center of the dividing plane; furthermore, these are precursors to new cell walls and are essential for cytokinesis.
Yumei Shi, Changxin Luo, Yun Xiang, Dong Qian   +3 more
doaj   +1 more source

Phylogenetic and Expression Studies of Small GTP-Binding Proteins in Solanum lycopersicum Super Strain B

Plants, 2022
This investigation involved a comparative analysis of the small GTPase superfamily in S. lycopersicum super strain B compared to their analogues in leguminous and other non-leguminous species.
H. Al-Zahrani, T. Moussa, H. Alsamadany, R. Hafez, M. Fuller   +4 more
semanticscholar   +1 more source