Results 121 to 130 of about 55,282 (252)

Abundance and subcellular distribution of GTP-binding proteins in 3T3-L1 cells before and after differentiation to the insulin-sensitive phenotype.

European Journal of Biochemistry, 1993
The abundance and the subcellular distribution of GTP-binding proteins was studied in membrane fractions (plasma membranes and low-density microsomes) from 3T3-L1 cells before and after differentiation to the insulin-sensitive phenotype.
C. Huppertz, A. Schürmann, H. Joost
semanticscholar   +1 more source

Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway

Advanced Science, Volume 12, Issue 8, February 24, 2025.
Circular RNA hsa_circ_0005185 functions as a molecular scaffold, facilitating the interaction between OTUB1 and RAB8A, leading to the deubiquitination of RAB8A. This process promotes primary cilia formation and enhances GLI3R production in the Hedgehog signaling pathway, ultimately inhibiting androgen receptor activity and suppressing the progression ...
Aoyu Fan, Yunyan Zhang, Yunpeng Li, Wei Meng, Fan Wu, Wei Pan, Zhongliang Ma, Wei Chen   +7 more
wiley   +1 more source

Functional studies of plasma membrane syntaxins in yeast [PDF]

, 2003
Syntaxins are required for fusion of membranes in eukaryotic cells and belong to a group of proteins known as t-SNAREs. This thesis primarily focuses on the role of the plasma membrane syntaxins Sso1p and Sso2p in the yeast Saccharomyces cerevisiae.
Öyen, Mattias
core  

Virtual Identification of Essential Proteins Within the Protein Interaction Network of Yeast [PDF]

, 2005
Topological analysis of large scale protein-protein interaction networks (PINs) is important for understanding the organisational and functional principles of individual proteins. The number of interactions that a protein has in a PIN has been observed to be correlated with its indispensability.
arxiv   +1 more source

Unlocking the Potential of Extracellular Vesicles in Cardiovascular Disease

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Extracellular vesicles (EVs) are micro‐nanoscale biological particles encapsulated by phospholipid bilayers, which regulate cell migration, angiogenesis and tumour cell growth by transmitting various biomolecules such as nucleic acids and proteins. EVs are composed of exosomes, microparticles and apoptotic bodies.
Hanbin Li, Lu Wang, Hongxin Cheng, Qing Zhang, Shiqi Wang, Wen Zhong, Chengqi He, Quan Wei   +7 more
wiley   +1 more source

Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization [PDF]

, 1993
The rab subfamily of small GTPases has been demonstrated to play an important role in the regulation of membrane traffic in eukaryotic cells. Compared with nonpolarized cells, epithelial cells have distinct apical and basolateral transport pathways which
Chavrier, P., Huber, L. A., Jansson, S., Lehtonen, E., Lutcke, A., Parton, R. G., Valencia, A., Zerial, M.   +7 more
core   +1 more source

Effect of symmetry on the electronic DOS, charge fluctuations and electron-phonon coupling in carbon chains [PDF]

arXiv, 2016
A theoretical model is provided to address the parameters influencing the electronic properties of kink-structured carbon chain at 0K. It is studied by the principle of DFT and solving the numerical 1D time-independent Schr\"odinger equation of electron and phonon simultaneously.
arxiv  

Length, Protein-Protein Interactions, and Complexity [PDF]

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv   +1 more source

Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders [PDF]

, 2008
Ras-associated binding (Rab) proteins and Rab-associated proteins are key regulators of vesicle transport, which is essential for the delivery of proteins to specific intracellular locations.
A Abderrahmani, A Prada-Delgado, A Vossenkämper, AN Hume, C Alvarez-Dominguez, E Denayer, E Pastural, EH Sklan, F Schuster, G Ménasché, GE Janka, IA Aligianis, IA Aligianis, JB Pereira-Leal, JC Patel, JC Stinchcombe, JH Robben, JS Anant, K Alexandrov, K Croizet-Berger, K Verhoeven, K Verhoeven, Kathleen Freson, Lucien Corbeel, M Geppert, M Strom, MC Seabra, MC Seabra, MC Seabra, O Ullrich, P D’Adamo, P Gissen, RG Russell, S Méresse, SD Der, SM Ostrowski, SR Pfeffer, SR Pfeffer, T Aizawa, T Imamura, WT Garvey, Y Parman   +41 more
core   +2 more sources

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus [PDF]

, 1994
We have examined the modifications occurring during the transformation of phagosomes into phagolysosomes in J-774 macrophages. The use of low density latex beads as markers of phagosomes (latex bead compartments, LBC) allowed the isolation of these ...
Desjardins, M., Griffiths, G., Huber, L. A., Parton, R. G.   +3 more
core   +4 more sources