Results 41 to 50 of about 55,282 (252)
Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
Molecular Neurodegeneration, 2018 Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain
Ga Ram Jeong +12 more
doaj +1 more source
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. [PDF]
PLoS Genetics, 2012 A significant percentage of young men are infertile and, for the majority, the underlying cause remains unknown. Male infertility is, however, frequently associated with defective sperm motility, wherein the sperm tail is a modified flagella/cilia ...
Jennifer C Y Lo +13 more
doaj +1 more source
Myotubularin MTM1 Involved in Centronuclear Myopathy and its Roles in Human and Yeast Cells [PDF]
Journal of Molecular and Genetic Medicine, OMICS International,
2015, 08 (02), 2018 Mutations in the MTM1 gene, encoding the phosphoinositide phosphatase myotubularin, are responsible for the X-linked centronuclear myopathy (XLCNM) or X-linked myotubular myopathy (XLMTM). The MTM1 gene was first identified in 1996 and its function as a PtdIns3P and PtdIns(,5)P2 phosphatase was discovered in 2000.
arxiv +1 more source
Journal of Clinical Investigation, 1996 Several GTP-binding proteins (G-proteins) undergo post-translational modifications (isoprenylation and carboxyl methylation) in pancreatic beta cells. Herein, two of these were identified as CDC42 and rap 1, using Western blotting and immunoprecipitation.
A. Kowluru +8 more
semanticscholar +1 more source
Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation [PDF]
, 2015 Rab GTPases control membrane identity, fusion, and transport by interaction with effector proteins. Effectors that influence the activation/inactivation cycle of their own or other Rabs contribute to the timely conversion of Rab identities.
Buser, Dominik P. +3 more
core +1 more source
Characterization of the Populus Rab family genes and the function of PtRabE1b in salt tolerance
BMC Plant Biology, 2018 Background Rab proteins form the largest family of the Ras superfamily of small GTP-binding proteins and regulate intracellular trafficking pathways. However, the function of the Rab proteins in woody species is still an open question.
Jin Zhang +8 more
doaj +1 more source
Thermodynamic Uncertainty Relation in the interlinked cascade of RabGTPases [PDF]
arXiv, 2022 We model the well-known interlinked cascade of Rab GTPases found in eukaryotic cells by using a network of Markov states to investigate the universal Thermodynamic Uncertainty Relation for the non-equilibrium system. First, we prove numerically the TUR in both single Rab species model and the interlinked two Rab species model.
arxiv
Biochemical Journal, 1993 Many GTP-binding proteins (GBPs) are modified by mevalonic acid (MVA)-dependent isoprenylation, carboxyl methylation or palmitoylation. The effects of inhibitors of these processes on insulin release were studied.
Stewart A. Metz +3 more
semanticscholar +1 more source
Autophagy in Saccharomyces cerevisiae requires the monomeric GTP-binding proteins, Arl1 and Ypt6
Autophagy, 2016 Macroautophagy/autophagy is a cellular degradation process that sequesters organelles or proteins into a double-membrane structure called the phagophore; this transient compartment matures into an autophagosome, which then fuses with the lysosome or ...
Shu Yang, A. Rosenwald
semanticscholar +1 more source
Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [PDF]
, 2012 Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes.
Cox, Sarah +4 more
core +1 more source