Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
Molecular Neurodegeneration, 2018 Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain
Ga Ram Jeong +12 more
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Topological and functional properties of the small GTPases protein interaction network. [PDF]
PLoS ONE, 2012 Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
doaj +1 more source
Intrinsic tethering activity of endosomal Rab proteins. [PDF]
, 2011 Rab small G proteins control membrane trafficking events required for many processes including secretion, lipid metabolism, antigen presentation and growth factor signaling.
Brett, Christopher L +6 more
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RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. [PDF]
PLoS Genetics, 2012 A significant percentage of young men are infertile and, for the majority, the underlying cause remains unknown. Male infertility is, however, frequently associated with defective sperm motility, wherein the sperm tail is a modified flagella/cilia ...
Jennifer C Y Lo +13 more
doaj +1 more source
Characterization of the Populus Rab family genes and the function of PtRabE1b in salt tolerance
BMC Plant Biology, 2018 Background Rab proteins form the largest family of the Ras superfamily of small GTP-binding proteins and regulate intracellular trafficking pathways. However, the function of the Rab proteins in woody species is still an open question.
Jin Zhang +8 more
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HUNK Phosphorylates Rubicon to Support Autophagy [PDF]
, 2019 Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex.
Abt, Melissa +5 more
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The rab3A-22A chimera prevents sperm exocytosis by stabilizing open fusion pores [PDF]
, 2016 At the final stage of exocytotis, a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore dilates the vesicle releases its cargo.
Bustos, Matias Alberto +5 more
core +1 more source
Autophagy in Saccharomyces cerevisiae requires the monomeric GTP-binding proteins, Arl1 and Ypt6
Autophagy, 2016 Macroautophagy/autophagy is a cellular degradation process that sequesters organelles or proteins into a double-membrane structure called the phagophore; this transient compartment matures into an autophagosome, which then fuses with the lysosome or ...
Shu Yang, A. Rosenwald
semanticscholar +1 more source
The Ras protein superfamily: Evolutionary tree and role of conserved amino acids [PDF]
, 2012 The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site.
Fuentes, Gloria +3 more
core +1 more source
TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells [PDF]
, 2014 Rab11a is a key modulator of vesicular trafficking processes, but there is limited information about the guanine nucleotide-exchange factors and GTPase-activating proteins (GAPs) that regulate its GTP-GDP cycle. We observed that in the presence of Mg(2+)
Apodaca, Gerard +9 more
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