Results 81 to 90 of about 55,282 (252)
Membrane trafficking of synaptic adhesion molecules
The Journal of Physiology, EarlyView.Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley +1 more source
Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation [PDF]
, 2009 Rab GTPases are molecular switches that orchestrate vesicular trafficking, maturation and fusion by cycling between an active, GTP-bound form, and an inactive, GDP-bound form.
Andres +59 more
core +2 more sources
PLoS ONE, 2018 Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes
Madalene Earp +148 more
doaj +1 more source
Airborne Urban Microcells with Grasping End Effectors: A Game Changer for 6G Networks? [PDF]
arXiv, 2021 Airborne (or flying) base stations (ABSs) embedded on drones or unmanned aerial vehicles (UAVs) can be deemed as a central element of envisioned 6G cellular networks where significant cell densification with mmWave/Terahertz communications will be part of the ecosystem.
arxiv
Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins
The Journal of Physiology, EarlyView.Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape +4 more
wiley +1 more source
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
Molecular Neurodegeneration, 2018 Background Mutations in LRRK2 are a common genetic cause of Parkinson’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centrosome-related events. However, the
Jesús Madero-Pérez +21 more
doaj +1 more source
Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.Abstract INTRODUCTION Down syndrome (DS) markedly raises the risk of Alzheimer's disease (DS‐AD). Our findings identified widespread dysregulation of the endolysosomal network (ELN) in DS and DS‐AD brains, driven by increased APP gene dose, hyperactivation of RAB5, and elevated levels of guanine nucleotide exchange factors (GEFs) for RABs 7 and 11 ...
Xu‐Qiao Chen +12 more
wiley +1 more source
Journal of Lipid Research, 2008 Formation of covalently bound protein adducts with lithocholic acid (LCA) might explain LCA's known carcinogenic properties and hepatotoxicity. We performed studies aimed at isolating and identifying hepatic proteins tagged with LCA, presumably via the ε-
Shigeo Ikegawa +6 more
doaj
Experimental parasitology, 1995 Members of the rab subfamily of GTPases have been implicated as important components in vesicle trafficking in the eukaryotes. Individual rab proteins have a remarkable degree of specific subcellular localization.
Mark C. Field, J. Boothroyd
semanticscholar +1 more source
Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.Abstract INTRODUCTION Down syndrome (DS) markedly increases the risk of Alzheimer's disease (DS‐AD), but the role of RAB5 hyperactivation in its pathogenesis remains unclear. METHODS Postmortem brain samples from individuals with DS, with and without AD, and a partial trisomy 21 case with only two amyloid precursor protein (APP) gene copies, were ...
Xu‐Qiao Chen +3 more
wiley +1 more source