Results 131 to 140 of about 78,155 (186)

Spatial Cycling of Rab GTPase, Driven by the GTPase Cycle, Controls Rab’s Subcellular Distribution

, 2019
Rab GTPases (>60 members in humans) function as master regulators of intracellular membrane trafficking. Correct and specific localization of Rab proteins is required for their function. How the distinct spatial distribution of Rab GTPases in the cell is
Wu, Yao-Wen,, Voss, Stephanie, Stephanie Voss (6198881), Matthias Röger, Röger, M., Roeger, Matthias, Li, Fu, Yao-Wen Wu, Yao-Wen Wu (497870), Li, Fu,, Matthias Röger (6198887), Stephanie Voss, Rätz, A., Andreas Rätz (6198884), Li, F., Voss, S., Andreas Rätz, Raetz, Andreas, Wu, Yao-Wen, Wu, Y., Fu Li (446847), Fu Li   +21 more
core   +1 more source

Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells. [PDF]

Mol Oncol, 2023
Chang YC, Li CH, Chan MH, Fang CY, Zhang ZX, Chen CL, Hsiao M.   +6 more
europepmc   +1 more source

Identification and verification of Sro7p as an effector of the Sec4p Rab GTPase.

, 2008
Effectors are operationally defined as proteins that recognize a specific GTPase preferentially in its GTP-bound conformation. Here we present the use of affinity chromatography to identify potential effectors of Sec4p, the Rab GTPase that controls the ...
Grosshans, Bianka, Novick, Peter
core  

Rab GTPase Expression Changes in α-Synucleinopathy and Tauopathy Disorders (P3.8-041)

, 2019
Objective: Determine Rab GTPase expression changes in α-synucleinopathy and tauopathy disorders. Background: Alterations in Rab GTPase function are increasingly implicated in neurodegenerative disease pathology.
Ma, Nathaniel, McFarland, Nikolaus, Bae, Gina, Parmar, Mayur S., Jadvani, Shivang   +4 more
core   +1 more source

Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A‐Mediated Endolysosomal Trafficking and Degradation of EGFR

Advanced Science
Hepatocellular carcinomas (HCCs) are characterized by a vast spectrum of somatic copy number alterations (CNAs); however, their functional relevance is largely unknown.
Pengbo Cao, Hongxia Chen, Ying Zhang, Qi Zhang, Mengting Shi, Huihui Han, Xiaowen Wang, Liang Jin, Bingqian Guo, Rongjiao Hao, Xi Zhao, Yuanfeng Li, Chengming Gao, Xinyi Liu, Yahui Wang, Aiqing Yang, Chenning Yang, Anfeng Si, Hua Li, Qingfeng Song, Fuchu He, Gangqiao Zhou   +21 more
doaj   +1 more source

Protein kinase A participates in hyphal and appressorial development by targeting Efg1-mediated transcription of a Rab GTPase in Setosphaeria turcica. [PDF]

Mol Plant Pathol, 2022
Liu Y, Shen S, Hao Z, Wang Q, Zhang Y, Zhao Y, Tong Y, Zeng F, Dong J.   +8 more
europepmc   +1 more source

Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network. [PDF]

Mol Biol Cell, 2021
Thomas LL, Highland CM, Fromme JC.
europepmc   +1 more source

Rit1-TBC1D10B signaling modulates FcγR-mediated phagosome formation in RAW264 macrophages

Life Science Alliance
During phagocytosis, the signaling molecule Rit1 GTPase promotes the dissociation of TBC1D10B from the phagocytic membrane, thereby disinhibiting phagosome formation mediated by TBC1D10B.
Youhei Egami, Katsuhisa Kawai, Nobukazu Araki   +2 more
doaj   +1 more source

The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan. [PDF]

PLoS Genet, 2022
Meraş İ, Chotard L, Liontis T, Ratemi Z, Wiles B, Seo JH, Van Raamsdonk JM, Rocheleau CE.   +7 more
europepmc   +1 more source

The Rab GTPase-binding protein EHBP1L1 and its interactors CD2AP/CIN85 negatively regulate the length of primary cilia via actin remodeling. [PDF]

J Biol Chem, 2023
Iwano T, Sobajima T, Takeda S, Harada A, Yoshimura SI.   +4 more
europepmc   +1 more source